James, David A, Keizo Koya, Hao Li, Guiqing Liang, Zhiqiang Xia, Weiwen Ying, Yaming Wu, and Lijun Sun. 2008. “Indole- and Indolizine-Glyoxylamides Displaying Cytotoxicity Against Multidrug Resistant Cancer Cell Lines.”. Bioorganic & Medicinal Chemistry Letters 18 (6): 1784-7.
Abstract
We report herein the SAR studies of a series of indole- and indolizine-glyoxylamides that demonstrate substantial in vitro anti-proliferative activities against cancer cell lines, including multidrug resistance (MDR) phenotypes. The in vitro cytotoxic effects have been demonstrated across a wide array of tumor types of various origins (e.g., breast, colon, uterine).