Found in translation of mTOR signaling.
Clohessy, John G, Markus Reschke, and Pier Paolo Pandolfi. 2012. “Found in Translation of MTOR Signaling.”. Cell Research 22 (9): 1315-8.
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Pro-senescence therapy for cancer treatment.
Nardella, Caterina, John G Clohessy, Andrea Alimonti, and Pier Paolo Pandolfi. 2011. “Pro-Senescence Therapy for Cancer Treatment.”. Nature Reviews. Cancer 11 (7): 503-11.
The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model.
Cheng, Ke, Paolo Sportoletti, Keisuke Ito, John G Clohessy, Julie Teruya-Feldstein, Jeffery L Kutok, and Pier Paolo Pandolfi. 2010. “The Cytoplasmic NPM Mutant Induces Myeloproliferation in a Transgenic Mouse Model.”. Blood 115 (16): 3341-5.
Npm1 is a haploinsufficient suppressor of myeloid and lymphoid malignancies in the mouse.
Sportoletti, Paolo, Silvia Grisendi, Samia M Majid, Ke Cheng, John G Clohessy, Agnes Viale, Julie Teruya-Feldstein, and Pier Paolo Pandolfi. 2008. “Npm1 Is a Haploinsufficient Suppressor of Myeloid and Lymphoid Malignancies in the Mouse.”. Blood 111 (7): 3859-62.
In Vitro Target Validation
Target validation of agents or combinations of agents in cell culture in one or more murine and human tumor cell lines or mouse embryonic fibroblasts (MEFs) of various genotypes (see below). Use of several different assays depending upon the agent and type of information sought. Availability of an...
PI3K drives the de novo synthesis of coenzyme A from vitamin B5.
Dibble, Christian C, Samuel A Barritt, Grace E Perry, Evan C Lien, Renee C Geck, Sarah E DuBois-Coyne, David Bartee, et al. 2022. “PI3K Drives the de Novo Synthesis of Coenzyme A from Vitamin B5.”. Nature 608 (7921): 192-98.
WWP1 inactivation enhances efficacy of PI3K inhibitors while suppressing their toxicities in breast cancer models.
Kishikawa, Takahiro, Hiroshi Higuchi, Limei Wang, Nivedita Panch, Valerie Maymi, Sachem Best, Samuel Lee, et al. 2021. “WWP1 Inactivation Enhances Efficacy of PI3K Inhibitors While Suppressing Their Toxicities in Breast Cancer Models.”. The Journal of Clinical Investigation 131 (24).
NF-κB Blockade with Oral Administration of Dimethylaminoparthenolide (DMAPT), Delays Prostate Cancer Resistance to Androgen Receptor (AR) Inhibition and Inhibits AR Variants.
Morel, Katherine L, Anis A Hamid, John G Clohessy, Nicole Pandell, Leigh Ellis, and Christopher J Sweeney. 2021. “NF-κB Blockade With Oral Administration of Dimethylaminoparthenolide (DMAPT), Delays Prostate Cancer Resistance to Androgen Receptor (AR) Inhibition and Inhibits AR Variants.”. Molecular Cancer Research : MCR 19 (7): 1137-45.
Targeting microtubules sensitizes drug resistant lung cancer cells to lysosomal pathway inhibitors.
Chin, Tan-Min, Gandhi T K Boopathy, Ellen P S Man, John G Clohessy, Eva Csizmadia, Margaret P Quinlan, Thomas Putti, et al. 2020. “Targeting Microtubules Sensitizes Drug Resistant Lung Cancer Cells to Lysosomal Pathway Inhibitors.”. Theranostics 10 (6): 2727-43.
Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway.
Lee, Yu-Ru, Ming Chen, Jonathan D Lee, Jinfang Zhang, Shu-Yu Lin, Tian-Min Fu, Hao Chen, et al. 2019. “Reactivation of PTEN Tumor Suppressor for Cancer Treatment through Inhibition of a MYC-WWP1 Inhibitory Pathway.”. Science (New York, N.Y.) 364 (6441).