Dr. Shaoyong Chen

Dr. Shaoyong Chen is a researcher in the Hematology-Oncology Division of the Department of Medicine at Beth Israel Deaconess Medical Center (BIDMC) and Harvard Medical School. His academic background includes a Ph.D. in Medical Science from Nagoya University in Japan (2001–2005) and subsequent postdoctoral training in cancer biology at BIDMC beginning in 2008. 
His scientific interests primarily focus on the molecular mechanisms of prostate cancer (PCa), with a specific emphasis on the dual role of the androgen receptor (AR). Dr. Chen investigates how the AR functions not only as a transcriptional activator that drives tumor growth but also as a transcriptional repressor that can suppress proliferation under certain conditions. His research explores the intricate balance between AR and MYC signaling, the impact of androgen deprivation on tumor evolution, and the role of chromatin organization and epigenetic alterations in driving castration-resistant prostate cancer. Additionally, his work has examined the function of AR splice variants and the influence of co-factors like protein phosphatase 1 (PP1) on AR activity.