Taplin, Mary-Ellen, and Steven P Balk. (2015) 2015. “Has the Time Arrived for Biomarker-Directed Therapy in Castration-Resistant Prostate Cancer?”. JAMA Oncology 1 (5): 577-9. https://doi.org/10.1001/jamaoncol.2015.1457.
Publications by Year: 2015
2015
Plymate, Stephen R, Rupal S Bhatt, and Steven P Balk. (2015) 2015. “Taxane Resistance in Prostate Cancer Mediated by AR-Independent GATA2 Regulation of IGF2.”. Cancer Cell 27 (2): 158-9. https://doi.org/10.1016/j.ccell.2015.01.008.
GATA2 has been well-characterized as a critical pioneer transcription factor for androgen receptor (AR) in prostate cancer. In this issue of Cancer Cell, Vidal and colleagues identify increased GATA2 and its AR-independent transactivation of IGF2 as a mechanism that can mediate taxane resistance through activation of IGF1/insulin receptor signaling.