Uner, Aaron Aykut, Won-Mo Yang, Min-Cheol Kang, Kellen Cristina da Cruz Rodrigues, Ahmet Aydogan, Ji A Seo, Natalia F Mendes, et al. 2023. “LRP1 Mediates Leptin Transport by Coupling With the Short-Form Leptin Receptor in the Choroid Plexus.”. BioRxiv : The Preprint Server for Biology.
Abstract
Adipocyte-derived leptin enters the brain to exert its anorexigenic action, yet its transport mechanism is poorly understood. Here we report that LRP1 (low-density lipoprotein receptor-related protein-1) mediates the transport of leptin across the blood-CSF barrier in Foxj1 expressing cells highly enriched at the choroid plexus (ChP), coupled with the short-form leptin receptor, and LRP1 deletion from ependymocytes and ChP cells leads to leptin resistance and hyperphagia, causing obesity. Thus, LRP1 in epithelial cells is a principal regulator of leptin transport in the brain.