Sable Systems Promethion indirect calorimeter (32 cages)
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Food intake
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Water intake
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In-cage body mass measurement
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Physical activity (infrared beam breaks)
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Energy expenditure
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Oxygen consumption (VO2)
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Carbon dioxide production (VCO2)
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Respiratory exchange ratio – an indicator of carbohydrate or fat substrate oxidation
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Wheels for voluntary running
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Food access control gates for timed fast/feeding and pair feeding studies
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Environmental temperature-controlled (6°C to 38°C)
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Environmental light control for circadian studies (light/dark, dark/dark, dark/light)
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Telemetry receivers to record body temperature and heart rate (STARR TELEMETRY)
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Continuous glucose monitoring and body temperature (DSI) for up to 8 mice
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Isotopic analyzer to measure in vivo whole-body oxidation rates of substrates (e.g. 13C-glucose or 18O-glucose) into 13CO2 or C18O2 for up to 24 mice
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Sterile isolator cages for measurement of germ-free mice or with defined populations of microbes (gnotobiotic mice) in collaboration and coordination with the Massachusetts Host-Microbiome Center
A Promethion home cage with a smooth cage bottom, bedding, running wheel, food and drink hoppers, and a body weight sensor (in red). Activity is monitored by an infrared beam manifold in black around the perimeter of the cage.