Agustin Melo Carrillo, M.D., PhD received an RO1 grant from the NIH/NINDS (National Institute of Neurological Disorders and Stroke) for his Project “Elucidating the nociceptive mechanisms of CGRP in migraine.” The total and indirect amount of this five-year grant is $1,945,825.
Dr. Melo Carrillo discusses his Project below.
"Calcitonin gene-related peptide (CGRP) has been implicated as playing a critical role in the generation of migraine headache, but there is a fundamental gap in our understanding in that none of the known properties provide a basis for explaining how it would have the ability to generate head pain. To address this gap, we have developed a new experimental approach that allows us for the first time to study nociceptive neuronal activation by CGRP, and investigate its site and mechanisms of action. A greater understanding of these mechanisms will potentially lead to novel therapeutic strategies in headache management, and help to bridge the gap between experimental findings and clinical application."