Saper, CB. (2025) 2025. “Targeting Orexin Neurons to Treat Narcolepsy”. New Engl J Med 392: 1968-71.
Publications
2025
Machado, NLS, N Lynch, LHA Costa, D Melville, H Kucukdereli, S Kaur, AS Banks, et al. (2025) 2025. “Preoptic EP3R Neurons Constitute a Two-Way Switch for Fever and Torpor”. Nature doi: 10.1038/s41586-025-09056-1.
2024
Nardone, S., R. De Luca, A. Zito, N. Klymko, D. Nicoloutsopoulos, O. Amsalem, C. Brannigan, et al. 2024. “A Spatially-Resolved Transcriptional Atlas of the Murine Dorsal Pons at Single-Cell Resolution”. Nat Commun 15 (1): 1966. https://doi.org/10.1038/s41467-024-45907-7.
Kaur, S., N. Lynch, Y. Sela, J. D. Lima, R. C. Thomas, S. S. Bandaru, and C. B. Saper. 2024. “Lateral Parabrachial FoxP2 Neurons Regulate Respiratory Responses to Hypercapnia”. Nat Commun 15 (1): 4475. https://doi.org/10.1038/s41467-024-48773-5.
2023
Machado, N. L. S., F. Raffin, S. Kaur, A. S. Banks, N. Lynch, O. Fanari, O. R. Plascencia, et al. 2023. “Prolonged Activation of EP3 Receptor-Expressing Preoptic Neurons Underlies Torpor Responses”. Res Sq. https://doi.org/10.21203/rs.3.rs-2861253/v1.
Agostinelli, L. J., S. C. Seaman, C. B. Saper, D. P. Fykstra, M. M. Hefti, T. R. Koscik, B. J. Dlouhy, and A. G. Bassuk. 2023. “Human Brainstem and Cerebellum Atlas: Chemoarchitecture and Cytoarchitecture Paired to MRI”. J Neurosci 43 (2): 221-39. https://doi.org/10.1523/jneurosci.0587-22.2022.
2022
Machado, N. L. S., W. D. Todd, S. Kaur, and C. B. Saper. 2022. “Median Preoptic GABA and Glutamate Neurons Exert Differential Control over Sleep Behavior”. Curr Biol 32 (9): 2011-21. https://doi.org/10.1016/j.cub.2022.03.039.
De Luca, R., S. Nardone, K. P. Grace, A. Venner, M. Cristofolini, S. S. Bandaru, L. T. Sohn, et al. 2022. “Orexin Neurons Inhibit Sleep to Promote Arousal”. Nat Commun 13 (1): 4163. https://doi.org/10.1038/s41467-022-31591-y.
2021
Saper, C. B. 2021. “The Intermediate Nucleus in Humans: Cytoarchitecture, Chemoarchitecture, and Relation to Sleep, Sex, and Alzheimer Disease”. Handb Clin Neurol 179: 461-69. https://doi.org/10.1016/b978-0-12-819975-6.00030-3.
2020
Machado, N. L. S., S. S. Bandaru, S. B. G. Abbott, and C. B. Saper. 2020. “EP3R-Expressing Glutamatergic Preoptic Neurons Mediate Inflammatory Fever”. J Neurosci 40 (12): 2573-88. https://doi.org/10.1523/jneurosci.2887-19.2020.