About Us

The BIDMC Biomarker Discovery Center has over 20 years of experience in precision medicine and proteomics biomarker discovery in tissue and biological fluids. We are the only lab in Boston to run the highly multiplex 11,000-protein SomaScan v5.0 assay.

State-of-the-Art Technologies

The Genomics and Proteomics Core at BIDMC provides all the tools of modern functional genomics and proteomics for academic and corporate clients alike, including state-of-the-art technologies for

• Proteomics
• Transcriptional profiling
• Genotyping
• Real-time-PCR
• Robotics

SOMAscan

We have recently added the exciting and powerful new, cutting-edge proteomics assay, SOMAscan, from SomaLogic. The core is the exclusive service provider for this 1310 protein biomarker discovery platform in the Boston/Longwood Medical Area.

SOMAscan (SomaLogic) is a high multiplex, high sensitivity aptamer-based immune-like protein and biomarker discovery platform that simultaneously quantifies 1,310 human proteins in all types of protein extracts from bodily fluids such as serum, plasma, urine, saliva, CSF, cyst fluid, and tissue, cells, lavage, animal models and exosomes.

SOMAmers are modified DNA aptamers with high affinity and specificity

Converts a measured protein level into a DNA signal

DNA microarray readout

All biological fluids: serum/plasma (35  ul), CSF (15 ul), urine, synovial fluid, etc.

All exosomes, cell and tissue extracts (2.4 ug of protein)

Designed for human proteins; works well for other species (primates, mouse, rat, pig, sheep)

SomaScan as an Effective Tool for Disease and Therapeutic Response Biomarker Discovery and Validation