Scherlinger, M., & Tsokos, G. C. (2021). Shortage of aspartate in mitochondria fuels arthritis. Nat Immunol, 22, 1474-1476.
Abstract
In patients with rheumatoid arthritis, a short supply of aspartate in the mitochondria can force the endoplasmic reticulum of T cells to generate transmembrane TNF, which in turn contributes to synovial inflammation.
Last updated on 02/17/2024