James, David A, Keizo Koya, Hao Li, Shoujun Chen, Zhiqiang Xia, Weiwen Ying, Yaming Wu, and Lijun Sun. 2006. “Conjugated Indole-Imidazole Derivatives Displaying Cytotoxicity Against Multidrug Resistant Cancer Cell Lines.”. Bioorganic & Medicinal Chemistry Letters 16 (19): 5164-8.
Abstract
We report herein the SAR studies of a series of indole-imidazole compounds. that demonstrate substantial in vitro anti-proliferative activities against cancer cell lines, including multidrug resistance (MDR) phenotypes. The in vitro cytotoxic effects have been demonstrated across a wide array of tumor types, including hematologic and solid tumor cell lines of various origins (e.g., leukemia, breast, colon, and uterine).