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The Freedman Lab, a component of the Musculoskeletal Translation Innovation Initiative (MTII) at BIDMC, has a primary focus on pioneering innovative solutions to address unmet clinical needs within the musculoskeletal (MSK) domain. Our capabilities encompass a range of disciplines including...

Nuclei Isolation from human cortical tissue for enrichment of endothelial and microglial cells Click Here GitHub for scripts, data, and protocols

Katherine (Katie) Van Schaik, MD, PhD, MA, one of our previous diagnostic radiology residents, was also an American Board of Radiology (ABR) Holman Research Pathway Scholar . Named for nuclear medicine pioneer B. Leonard Holman, MD, and established in 1999, this national training program allows...

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We found that lin-4 mutants have short lifespans, while lin-4 over-expression extends lifespan and slows aging [1]. This was the first report of a role for miRNAs in regulating lifespan, and led to an intense study in my lab of roles for miRNAs in aging. Initially, we performed high throughput...