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Highly Cited Research from the Core
Many discoveries have relied upon careful measurement of body composition and metabolic rates in un-anesthetized, freely moving mice. One metric to determine the impact of a scientific publication is how many times other scientific articles have referred to that work–or citations. Selected highly...
Pharmacologic induction of metabolic rate (T3)
C57Bl/6J male mice were monitored in the Promethion indirect calorimeter, and data were analyzed in CalR to compare energy expenditure between T3-treated and vehicle groups (Hochbaum et al., Cell, 2024).
Chemogenetic stimulation of metabolism
Mice expressing DREADDs and non-DREADD controls were monitored in the Promethion indirect calorimeter, with CNO administered at hour 4 and data plotted in CalR.
Induction of torpor
C57Bl/6J female mice were monitored for body temperature and metabolic rate during the dark photoperiod without food, with the blue trace representing a fed mouse and the red trace a fasted mouse exhibiting torpor (Hrvatin et al., Nature 2020).
Wheel running
Wheel-running activity was continuously recorded over several days, showing hourly running patterns and cumulative wheel counts across alternating light and dark cycles.
Contact
Alexander S. Banks Beth Israel Deaconess Medical Center Division Of Endocrinology, Diabetes, and Metabolism Center for Life Sciences, 7th floor 330 Brookline Ave Boston, MA 02115 Email: asbanks [at] bidmc.harvard.edu
An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ
Banks, Alexander S., Fiona E. McAllister, João Paulo G. Camporez, Peter-James H. Zushin, Michael J. Jurczak, Dina Laznik-Bogoslavski, Gerald I. Shulman, Steven P. Gygi, and Bruce M. Spiegelman. 2015. “An ERK/Cdk5 Axis Controls the Diabetogenic Actions of PPARγ”. Nature.
Effects of MEK inhibitors GSK1120212 and PD0325901 in vivo using 10-plex quantitative proteomics and phosphoproteomics
Paulo, Joao A., Fiona E. McAllister, Robert A. Everley, Sean A. Beausoleil, Alexander S. Banks, and Steven P. Gygi. 2015. “Effects of MEK Inhibitors GSK1120212 and PD0325901 in Vivo Using 10-Plex Quantitative Proteomics and Phosphoproteomics”. Proteomics.