Many discoveries have relied upon careful measurement of body composition and metabolic rates in un-anesthetized, freely moving mice. One metric to determine the impact of a scientific publication is how many times other scientific articles have referred to that work–or citations.
Selected highly cited publications (>100 citations) utilizing one or more of the facilities at the BIDMC are listed below:
- Mice lacking melanin-concentrating hormone are hypophagic and lean Shimada et al Nature 1998
- Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice Klaman et al MCB 2000
- βAR signaling required for diet-induced thermogenesis and obesity resistance Bachman et al Science 2002
- Melanin-concentrating Hormone Is a Critical Mediator of the Leptin-Deficient Phenotype Segal-Lieberman et al PNAS 2003
- Mice lacking ghrelin receptors resist the development of diet-induced obesity Zigman et al JCI 2005
- Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity Kershaw et al Diabetes 2005
- Mice with MCH ablation resist diet-induced obesity through strain-specific mechanisms Kokkotou et al AJP 2005
- TLR4 links innate immunity and fatty acid–induced insulin resistance Shi et al JCI 2006
- Neuronal PTP1B regulates body weight, adiposity and leptin action Bence et al Nature Medicine 2006
- A high-fat, ketogenic diet induces a unique metabolic state in mice Kennedy et al AJP 2007
- Voluntary exercise improves insulin sensitivity and adipose tissue inflammation in diet-induced obese mice Bradley et al AJP 2008
- Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle Martin et al JBC 2008
- Selective Inactivation of Socs3 in SF1 Neurons Improves Glucose Homeostasis without Affecting Body Weight Zhang et al Endocrinology 2008
- Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis Badman et al 2009 Endocrinology
- Leptin-dependent control of glucose balance and locomotor activity by POMC neurons Huo et al Cell Metabolism 2009
- Long-term Fenretinide treatment prevents high-fat diet-induced obesity, insulin resistance, and hepatic steatosis Preitner et al AJP 2009
- Rapid, reversible activation of AgRP neurons drives feeding behavior in mice Krashes et al JCI 2011
- Transcriptional control of adipose lipid handling by IRF4 Eguchi et al Cell Metabolism 2011
- Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons Vong et al Neuron 2011
- FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis Fisher et al Genes and Development 2012
- Fasting activation of AgRP neurons requires NMDA receptors and involves spinogenesis and increased excitatory tone Liu et al Neuron 2012
- IRF4 is a key thermogenic transcriptional partner of PGC-1α Kong et al Cell 2014
- Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity Kraus et al Nature 2014
- An Erk/Cdk5 axis controls the diabetogenic actions of PPARγ Banks et al Nature 2015
- Central fibroblast growth factor 21 browns white fat via sympathetic action in male mice Douris et al Endocrinology 2015
- PTH/PTHrP receptor mediates cachexia in models of kidney failure and cancer Kir et al Cell Metabolism 2016
- Genetic depletion of adipocyte creatine metabolism inhibits diet-induced thermogenesis and drives obesity Kazak et al Cell Metabolism 2017
Funding: the Energy Balance Core is sponsored by the BIDMC Department of Medicine and the Harvard Digestive Disease Centers