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Results - Obtained Under Urethane Anesthesia Regions that show activation during CMG peak include the Pontine Micturition Center (PMC), the Periaqueductal Gray (PAG) and the Hypothalamus. The PMC is a small center in the hindbrain that we now know activates bladder contractions, whereas the PAG...

In our laboratory, we study mechanisms of innate immune activation in liver diseases and its role on modulation of liver parenchymal cells including hepatocytes and stellate cells. We employ a broad range of preclinical murine liver injury models of alcohol-associated hepatitis, metabolic...

Biomarkers in Liver Disease We are exploring novel therapies and biomarker discoveries in AH. Direct effects of alcohol on hepatocytes, increased intestinal permeability and activation of innate immune system (Kupffer cells) by gut-derived LPS are major factors in AH leading to over-activation of...