In our laboratory, we study mechanisms of innate immune activation in liver diseases and its role on modulation of liver parenchymal cells including hepatocytes and stellate cells. We employ a broad range of preclinical murine liver injury models of alcohol-associated hepatitis, metabolic dysfunction-associated steatohepatitis (MASH), their combination (MetALD), drug-induced-liver injury, liver fibrosis and acute-on-chronic liver failure and study their relevance to human disease based on patient samples. Our recent focus is on the role of microRNAs and extracellular vesicles in immunoregulation in the pathogenesis of liver diseases. We are exploring inter-cellular and inter-organ communications in liver diseases with particular interest in the liver-gut-brain interaction.
