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Microvascular disease and early diabetes onset are associated with deficits in femoral neck bone density and structure among older adults with longstanding type 1 diabetes.

Publication: Journal Article

Johannesdottir, Fjola, Trinity Tedtsen, Laura M Cooke, Sarah Mahar, Meng Zhang, Jordan Nustad, Margaret A Garrahan, Sarah E Gehman, Elaine W Yu, and Mary L Bouxsein. 2024. “Microvascular Disease and Early Diabetes Onset Are Associated With Deficits in Femoral Neck Bone Density and Structure Among Older Adults With Longstanding Type 1 Diabetes.”. Journal of Bone and Mineral Research : The Official Journal of the American Society for Bone and Mineral Research 39 (10): 1454-63.

Fracture risk based on high-resolution peripheral quantitative computed tomography measures does not vary with age in older adults-the bone microarchitecture international consortium prospective cohort study.

Publication: Journal Article

Szulc, Pawel, Alyssa B Dufour, Marian T Hannan, Douglas P Kiel, Roland Chapurlat, Elisabeth Sornay-Rendu, Blandine Merle, et al. 2024. “Fracture Risk Based on High-Resolution Peripheral Quantitative Computed Tomography Measures Does Not Vary With Age in Older Adults-the Bone Microarchitecture International Consortium Prospective Cohort Study.”. Journal of Bone and Mineral Research : The Official Journal of the American Society for Bone and Mineral Research 39 (5): 561-70.

Total body irradiation is associated with long-term deficits in femoral bone structure but not mechanical properties in male rhesus macaques.

Publication: Journal Article

Barnet, Isabel R, Shannon R Emerzian, Ramina Behzad, Daniel J Brooks, Trinity Tedtsen, Marcela Granados, Sun Park, et al. 2024. “Total Body Irradiation Is Associated With Long-Term Deficits in Femoral Bone Structure But Not Mechanical Properties in Male Rhesus Macaques.”. Scientific Reports 14 (1): 23379.

Anna Wadhwa

Person: Graduate Student (Harvard-MIT Health Sciences and Technology)

Musculoskeletal health in aging, osteoporosis and diabetes

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Our research focuses on understanding musculoskeletal health, particularly in the context of aging, osteoporosis, diabetes (T1D and T2D). We employ advanced non-invasive and in vivo quantitative imaging techniques, along with ex vivo bone specimen analyses and preclinical studies, to assess bone and...

Mechanical Testing

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Although imaging is often used as a surrogate to evaluate bone fragility, direct measurements of mechanical strength are undoubtedly the gold standard for providing information about the mechanical integrity of bone. Our lab offers a variety of mechanical testing options for measuring the mechanical...

Collaborators

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We recognize the value of collaborations and are proud of our many collaborators, both current and past. Collaboration is at the heart of scientific progress, and we are happy to highlight some of our collaborations below: San Francisco Coordinating Center, The Osteoporotic Fractures in Men (MrOS)...

Bone changes post-sleeve gastrectomy in relation to body mass and hormonal changes.

Publication: Journal Article

Kaur, Snimarjot, Supritha Nimmala, Vibha Singhal, Deborah M Mitchell, Clarissa C Pedreira, Meghan Lauze, Hang Lee, et al. 2023. “Bone Changes Post-Sleeve Gastrectomy in Relation to Body Mass and Hormonal Changes.”. European Journal of Endocrinology 189 (3): 346-54.

Biomechanical CT to Assess Bone After Sleeve Gastrectomy in Adolescents With Obesity: A Prospective Longitudinal Study.

Publication: Journal Article

Huber, Florian A, Vibha Singhal, Shubhangi Tuli, Fatima C Stanford, Brian Carmine, Mary L Bouxsein, Madhusmita Misra, and Miriam A Bredella. 2023. “Biomechanical CT to Assess Bone After Sleeve Gastrectomy in Adolescents With Obesity: A Prospective Longitudinal Study.”. Journal of Bone and Mineral Research : The Official Journal of the American Society for Bone and Mineral Research 38 (7): 933-42.

The PYY/Y2R-deficient male mouse is not protected from bone loss due to Roux-en-Y gastric bypass.

Publication: Journal Article

Zahedi, Bita, Eileen J Daley, Daniel J Brooks, Michael Bruce, Leigh Townsend, Hans-Rudolf Berthoud, Mary L Bouxsein, and Elaine W Yu. 2023. “The PYY/Y2R-Deficient Male Mouse Is Not Protected from Bone Loss Due to Roux-en-Y Gastric Bypass.”. Bone 167: 116608.