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Health Policy Section at AHA Scientific Sessions 2025
November 25, 2025 The Health Care Policy Section had a brilliant time in New Orleans for the AHA Scientific Sessions 2025 (Nov 7-10), with six presentations by section trainees, five sessions moderated by members of our section, and Dr. Wadhera was invited to speak in two different sessions...
Thermogenesis: beta-adrenergic agonist activation
Male C57Bl/6J mice housed at thermoneutrality were administered the β-adrenergic agonist CL 316,243, and changes in oxygen consumption were continuously measured.
Body Temperature Measurement: Telemetry
Indirect calorimetry data for one mouse implanted with a glucose and body temperature telemetry probe in the Promethion indirect calorimeter (Rubio et al Mol Metabolism 2023)
Physical activity
Physical activity was monitored by infrared beam breaks in the Promethion indirect calorimeter for one hour in either a mouse with ad libitum access to food or shortly after food removal. (Rubio et al Mol Metabolism 2023)
Indirect Calorimetry Systems
Sable Systems Promethion Indirect Calorimeter (32 cages) Food intake Water intake In-cage body mass measurement Physical activity (infrared beam breaks) Energy expenditure Oxygen consumption (VO2) Carbon dioxide production (VCO2) Respiratory exchange ratio – an indicator of carbohydrate or fat...
Thermogenesis: cold temperature challenge
Male C57Bl/6J mice (10–14 weeks, JAX) were monitored in the Promethion indirect calorimeter at 30°C, 23°C, and 4°C, tracking body weight and energy expenditure, with data analyzed in CalR.
Pharmacologic induction of metabolic rate (T3)
C57Bl/6J male mice were monitored in the Promethion indirect calorimeter, and data were analyzed in CalR to compare energy expenditure between T3-treated and vehicle groups (Hochbaum et al., Cell, 2024).
Diet-induced obesity
Analysis of diet-induced obesity experiments in male C57Bl/6J mice on a low-fat diet (LFD) or high-fat diet (HFD), demonstrating differences in body weight, energy intake, expenditure, and balance (Banks et al., Nature Metabolism, 2025).
Chemogenetic stimulation of metabolism
Mice expressing DREADDs and non-DREADD controls were monitored in the Promethion indirect calorimeter, with CNO administered at hour 4 and data plotted in CalR.