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We’re excited to share that the Spatial Technologies Unit (STU) is now officially recognized as a Dana Farber Harvard Cancer Center DF/HCC Core. This new designation means that DF/HCC members are eligible for internal pricing on STU services, supported in part by the Cancer Center Support Grant...

We’re thrilled to welcome Dr. Arpita Kulkarni to BIDMC as Co-Director of the Functional Genomics and Bioinformatics Core. With deep expertise in single-cell biology, genomic technologies, and translational science, Arpita brings a strong track record of bridging cutting-edge omics platforms with...

A recent Cell publication by Drs. Samuel Vidal and Dan Barouch describes a next-generation mRNA-based tuberculosis (TB) vaccine that surpassed the performance of the century-old BCG vaccine in preclinical studies. The trivalent mRNA–lipid nanoparticle (LNP) vaccine, which combines three newly...

A recent Aging Cell publication by Drs. Alice Rodrigues, Jan Heng, and Frank Slack identified miR-30c-5p, found in extracellular vesicles from young mice, as a promising therapeutic for reversing age-related liver fibrosis. The treatment improved insulin sensitivity and extended health span—offering...

In a recent Nature Communications study, Dr. Annalisa Di Ruscio and team introduced aptaDiR, a novel RNA therapeutic engineered to silence DNMT1 and reverse abnormal DNA methylation in cancer. Delivered via lipid nanoparticles, aptaDiR reactivated tumor-suppressor genes and significantly reduced...

Two new studies, presented at HiRM and AACR, identified promising RNA biomarkers in breast cancer and Hodgkin lymphoma. At the heart of both efforts was the Detection Unit at BIDMC’s Precision RNA Medicine Core. What made these discoveries possible? High-throughput miRNA screening using Mirxes qPCR...

A recent PNAS publication from Dr. Frank Slack’s group uncovers TRIDENT, an EGFR-induced long non-coding RNA that plays a key role in tumor growth and chemoresistance in non–small cell lung cancer (NSCLC). The team shows that TRIDENT activates TRIM28-mediated DNA damage repair, allowing cancer cells...

Thank you to everyone who joined this year’s Core Science Day. Recordings of all presentations are now available. The talks showcase the capabilities of BIDMC’s scientific cores and highlight current research supported by these platforms. Explore the talks here: BIDMC Cores Science Day 2025 on Vimeo...