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Evan wrote a comprehensive review article on interferon regulatory factors (IRFs) in metabolism, with help from Zunair Ahmad and Wahab Kahloan. It just came out in Nature Reviews Endocrinology.

Congratulations to Shuai Yan — his paper was just published in Nature Communications. Shuai showed that IRF3 causes insulin resistance in adipocytes independent of any effect on body weight. The mechanism is via induction of an enzyme called AIG1, which encodes a hydrolase that destroys insulin...

Greg’s latest paper is available on BioRxiv. Using unique intra-patient controls, he shows that the adipose tissue of chronic lymphedema has a different complement of adipose stromal and progenitor cells (ASPCs), which confer a more pro-adipogenic and pro-lymphangiogenic environment. https://www...

Please check out the new paper from the Rosen lab (working in collaboration with Randy Seeley’s group at the University of Michigan) about changes in adipose tissue after two different weight loss strategies in mice. Margo Emont compared white adipose tissue from obese mice that received either...

The Rosen Lab is bidding a fond farewell to Greg Westcott and Winnie Zhang as 2025 draws to a close. Greg’s leadership has been instrumental in advancing our knowledge on lymphedema, while Winnie’s tenacity have been the driving force in bringing the IRS1 project to a successful completion. It has...

Established in 1944, the Endocrine Society’s Laureate Awards recognize the highest achievements in the endocrinology field, including groundbreaking research and innovations in clinical care. The Roy O. Greep Award for Outstanding Research recognizes meritorious contributions to research in...

Lab alumnus Frankie Heyward and his wife Evida recently welcomed their first child Evie Amera Heyward into the world. Congratulations Frankie and Evida!

Frankie Heyward’s paper was just published in Nature Communications. Frankie used cell-type specific profiling of gene expression and chromatin state in AgRP neurons to predict novel transcriptional mediators of leptin action. Surprisingly, his data suggested that IRF3 might work downstream of...

Erwei Li has been granted a two-year fellowship through the Charles A. King Trust Postdoctoral Fellowship Program. Additionally, Erwei has been promoted to the position of Instructor. Congratulations, Erwei!

We are thrilled to have Khushi and Eliza on board as research assistants in the Rosen and Tsai labs. Eliza joins us from St. Lawrence University, where she majored in biochemistry . Khushi arrives from the University of California, Irvine, bringing with her a background in neurobiology. Welcome!