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Extracellular Vesicles in Alcoholic Liver Disease: Basic and Pre-clinical Discovery A salient feature of alcoholic liver disease is Kupffer cell activation and recruitment of inflammatory monocytes and macrophages. These key cellular events of ALD pathogenesis may be mediated by extracellular...

Danger signals and pathways of macrophage activation in NASH Inflammatory cell activation drives diverse cellular programming in steatohepatitis. Our studies revealed that activation of the multiprotein complex, inflammasome, contributes to non-alcoholic steatohepatitis (NASH) involving the NLRP3...

Experiments proposed in this supplement will explore novel signaling molecules in alcohol-induced neuroinflammation and interactions between alcohol use and key pathways in the biology of neuroinflammation and AD dementia. Our studies will reveal new potential therapeutic targets in the dual insult...

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