Higher-order epistasis within Pol II trigger loop haplotypes.
Duan, Bingbing, Chenxi Qiu, Steve W Lockless, Sing-Hoi Sze, and Craig D Kaplan. 2024. “Higher-Order Epistasis Within Pol II Trigger Loop Haplotypes.”. Genetics 228 (4).
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Cis P-tau is a central circulating and placental etiologic driver and therapeutic target of preeclampsia.
Jash, Sukanta, Sayani Banerjee, Shibin Cheng, Bin Wang, Chenxi Qiu, Asami Kondo, Jan Ernerudh, Xiao Zhen Zhou, Kun Ping Lu, and Surendra Sharma. 2023. “Cis P-Tau Is a Central Circulating and Placental Etiologic Driver and Therapeutic Target of Preeclampsia.”. Nature Communications 14 (1): 5414.
Adiponectin signaling regulates urinary bladder function by blunting smooth muscle purinergic contractility.
Luo, Zhaobo, Ali Wu, Simon Robson, Seth L Alper, and Weiqun Yu. 2025. “Adiponectin Signaling Regulates Urinary Bladder Function by Blunting Smooth Muscle Purinergic Contractility.”. JCI Insight 10 (4).
Reciprocal antagonism of PIN1-APC/CCDH1 governs mitotic protein stability and cell cycle entry.
Ke, Shizhong, Fabin Dang, Lin Wang, Jia-Yun Chen, Mandar T Naik, Wenxue Li, Abhishek Thavamani, et al. 2024. “Reciprocal Antagonism of PIN1-APC/CCDH1 Governs Mitotic Protein Stability and Cell Cycle Entry.”. Nature Communications 15 (1): 3220.
Eating less can lead to a longer life: massive study in mice shows why
Mark Zeidel and Warren Hill were part of a large team led by Dr. Gary Churchill at The Jackson Laboratory in Bar Harbor Maine that just published in Nature the results of a study that followed 970 genetically diverse mice over four years. The results showed that caloric restriction and intermittent...
Novel peptidomimetic compounds attenuate hypoxic-ischemic brain injury in neonatal rats.
Chen, Xiaodi F, Brynn Kroke, Jun Ni, Christian Munoz, Mark Appleman, Bryce Jacobs, Tuong Tran, et al. 2025. “Novel Peptidomimetic Compounds Attenuate Hypoxic-Ischemic Brain Injury in Neonatal Rats.”. Experimental Neurology 386: 115151.
Yu lab shines light on the role of fat tissue directly regulating bladder function via adipose hormones
Lower urinary tract symptoms (LUTS) are strongly associated with obesity and type 2 diabetes but the reasons remain unclear. Weiqun Yu and his post-doctoral fellow Dr. Zhaobo Luo (pictured) have just published intriguing data in the journal JCI Insight, demonstrating that the fat hormone adiponectin...