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2024 BIDMC Annual Research Retreat

News: September 05, 2024

Simon Lab members attended the research retreat. Alejandra and Emily presented "Pharmacological stabilization of the retromer complex results in the reduction of α-synuclein accumulation and in the control of α-synuclein clearance pathways" and joined in conversations about the latest research at...

PGC-1α

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USP30

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Alejandra and Emily dive into research discussions during an engaging poster session

News: September 05, 2024

PGC-1α

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Simon Lab: Lunchtime Science Chatter After a Successful Poster Presentation

News: September 05, 2024

Our Scientific Approach

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Our lab focuses on unraveling the biochemistry and neuropathology underlying this complex neurodegenerative disorder. We take a systems-level approach to investigate the molecular mechanisms driving disease progression, particularly focusing on key protein pathways, including VPS35, USP30, LRRK2...

LRRK2 and Rab proteins

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Leucine-rich repeat kinase 2 (LRRK2) is a critical protein associated with the pathogenesis of Parkinson's disease (PD), particularly through its influence on the endolysosomal system and the clearance of alpha-synuclein (aSyn) aggregates. The G2019S mutation in LRRK2 is the most prevalent...