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Neuroinflammation and Alzheimer’s disease The pathological role of interferon signaling is emerging in neuroinflammatory disorders, yet, the specific role of Interferon Regulatory Factor 3 (IRF3) in neuroinflammation remains poorly understood. Here, we show that global IRF3 deficiency delays TLR4...

Gyongyi Szabo, MD, PhD, FAASLD, AGAF, FACP Mitchell T. Rabkin, M.D. Chair Professor of Medicine and Faculty Dean for Academic Affairs Harvard Medical School Chief Academic Officer Beth Israel Lahey Health and Beth Israel Deaconess Medical Center Email: gszabo1@bidmc.harvard.edu Executive Assistant...

In our laboratory, we study mechanisms of innate immune activation in liver diseases and its role on modulation of liver parenchymal cells including hepatocytes and stellate cells. We employ a broad range of preclinical murine liver injury models of alcohol-associated hepatitis, metabolic...

Biomarkers in Liver Disease We are exploring novel therapies and biomarker discoveries in AH. Direct effects of alcohol on hepatocytes, increased intestinal permeability and activation of innate immune system (Kupffer cells) by gut-derived LPS are major factors in AH leading to over-activation of...