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The Lawler lab has studied the structure and function of the members of the TSP gene family for more than 50 years. We have focused on the role of TSP-1 in the tumor microenvironment. This research has informed the development of a new cancer therapeutic that is currently being evaluated in murine...

Our studies on the effects of Fc3TSR in a preclinical model of pancreatic cancer were recently reported at the September AACR meeting in Boston. Abstract A040: Assessing the ability of Fc3TSR to remodel the tumor microenvironment and enhance efficacy of immunotherapeutics and chemotherapy in a...