About Jack Lawler

Jack Lawler has researched the structure and function of the members of the thrombospondin gene family for fifty years. He received his B.S. in Physics from Villanova University in 1971 and his Ph.D. in Physics from Boston College in 1976. He was a post-doctoral fellow at the Dana Farber Cancer Institute in the Structural Biology Laboratory where he performed the first purification and biochemical characterization of thrombo-spondin-1. In 1982, Dr. Lawler became Assistant Professor in the Department of Medicine at Tufts University Medical School and St. Elizabeth’s Hospital, Boston where he continued his work on the thrombospondins and identified spectrin mutants involved in hemolytic anemias. While Dr. Lawler was a visiting scientist in Richard Hynes' lab at MIT, he cloned and sequenced thrombospondin-1 and engineered the thrombospondin-1-null mouse. In 1988, Dr. Lawler became Associate Professor of Pathology at Harvard Medical School and Brigham and Women’s Hospital. Dr. Lawler’s current appointments are: Professor of Pathology at Harvard Medical School and Vice-Chair for Research in the Department of Pathology at the Beth Israel Deaconess Medical Center. He is currently performing preclinical studies of Fc3TSR with the goal of bringing this reagent to the clinic for the treatment of cancer. He has published over 200 peer-reviewed articles and reviews, and has co-authored the book “The Thrombospondin Gene Family”.