Recent Review Articles on the Thrombospondins
Thrombospondin-1 in vascular development, vascular function, and vascular disease. Liu B, Yang H, Song YS, Sorenson CM, Sheibani N. Semin Cell Dev Biol. 2024 Mar 1;155(Pt B):32-44. doi: 10.1016/j.semcdb.2023.07.011. Epub 2023 Jul 27. PMID: 37507331 Review.
Thrombospondins modulate cell function and tissue structure in the skeleton. Alford AI, Hankenson KD. Semin Cell Dev Biol. 2024 Mar 1;155(Pt B):58-65. doi: 10.1016/j.semcdb.2023.06.011. Epub 2023 Jul 7. PMID: 37423854 Review.
Thrombospondin-1 in drug activity and tumor response to therapies. Longhi E, Carminati L, Carlessi E, Belotti D, Taraboletti G. Semin Cell Dev Biol. 2024 Mar 1;155(Pt B):45-51. doi: 10.1016/j.semcdb.2023.06.009. Epub 2023 Jul 4. PMID: 37414720 Review.
Pathophysiological roles of thrombospondin-4 in disease development. Genaro K, Luo ZD. Semin Cell Dev Biol. 2024 Mar 1;155(Pt B):66-73. doi: 10.1016/j.semcdb.2023.06.007. Epub 2023 Jun 28. PMID: 37391348 Review.
Thrombospondins in the tumor microenvironment. Petrik J, Lauks S, Garlisi B, Lawler J. Semin Cell Dev Biol. 2024 Mar 1;155(Pt B):3-11. doi: 10.1016/j.semcdb.2023.05.010. Epub 2023 Jun 5. PMID: 37286406 Review.
Emerging functions of thrombospondin-1 in immunity. Kaur S, Roberts DD. Semin Cell Dev Biol. 2024 Mar 1;155(Pt B):22-31. doi: 10.1016/j.semcdb.2023.05.008. Epub 2023 May 29. PMID: 37258315 Free article. Review.
The TSP1-CD47-SIRPα interactome: an immune triangle for the checkpoint era. Montero E, Isenberg JS. Cancer Immunol Immunother. 2023 Sep;72(9):2879-2888. doi: 10.1007/s00262-023-03465-9. Epub 2023 May 22. PMID: 37217603 Free PMC article. Review.
Molecular evolution of the Thrombospondin superfamily. Tucker RP, Adams JC. Semin Cell Dev Biol. 2024 Mar 1;155(Pt B):12-21. doi: 10.1016/j.semcdb.2023.05.004. Epub 2023 May 16. PMID: 37202276 Free article. Review.
Thrombospondin-2 acts as a critical regulator of cartilage regeneration: A review. Niu J, Liu Y, Wang J, Wang H, Zhao Y, Zhang M. Medicine (Baltimore). 2023 Apr 25;102(17):e33651. doi: 10.1097/MD.0000000000033651. PMID: 37115081 Free PMC article. Review.
Controlled extracellular proteolysis of thrombospondins. Carminati L, Carlessi E, Longhi E, Taraboletti G. Matrix Biol. 2023 May;119:82-100. doi: 10.1016/j.matbio.2023.03.011. Epub 2023 Mar 30. PMID: 37003348 Free article. Review.
Why do humans need thrombospondin-1? Kaur S, Roberts DD. J Cell Commun Signal. 2023 Sep;17(3):485-493. doi: 10.1007/s12079-023-00722-5. Epub 2023 Jan 23. PMID: 36689135 Free PMC article. Review.
Counter regulation of tumor angiogenesis by vascular endothelial growth factor and thrombospondin-1. Lawler J. Semin Cancer Biol. 2022 Nov;86(Pt 2):126-135. doi: 10.1016/j.semcancer.2022.09.006. Epub 2022 Sep 30. PMID: 36191900 Review.
Endothelial Cell Behavior Is Determined by Receptor Clustering Induced by Thrombospondin-1. Morandi V, Petrik J, Lawler J. Front Cell Dev Biol. 2021 Mar 29;9:664696. doi: 10.3389/fcell.2021.664696. eCollection 2021. PMID: 33869231 Free PMC article. Review.
PDB Crystalographic Structures of Thrombospondin Domains
Structure of the C-terminal domain of human thrombospondin-2 1YO8
The thrombospondin-1 polymorphism Asn700Ser associated with coronary disease causes local and long-ranging changes in protein structure 2RHP
The crystal structure of the signature domain of cartilage oligomeric matrix protein 3FBY
Structure of a thrombospondin C-terminal fragment reveals a novel calcium core in the type 3 repeats 1UX6
Crystal structure of thrombospondin-1 N-terminal domain in P1 form at 1.85A resolution 2ES3
Crystal structure of thrombospondin-1 N-terminal domain at 1.45A resolution 2ERF
Crystal structure of thrombospondin-1 N-terminal domain in complex with fractionated heparin DP10 2OUH
Crystal structure of thrombospondin-1 N-terminal domain in complex with fractionated heparin DP8 2OUJ
Crystal structure of thrombospondin-1 N-terminal domain 1Z78
Crystal structure of thrombospondin-1 N-terminal domain in complex with fractionated arixtra 1ZA4
Crystal structure of the thrombospondin-1 type 1 repeats 1LSL
Crystal structure of thrombospondin-1 TSR domains 2 and 3 3R6B
Crystal structure of the O-fucosylated form of TSRs1-3 from the human thrombospondin-1 7YYK