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Recent Review Articles on the Thrombospondins Thrombospondin-1 in vascular development, vascular function, and vascular disease. Liu B, Yang H, Song YS, Sorenson CM, Sheibani N. Semin Cell Dev Biol. 2024 Mar 1;155(Pt B):32-44. doi: 10.1016/j.semcdb.2023.07.011. Epub 2023 Jul 27. PMID: 37507331...

Clinical Development of Fc3TSR

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TSP-1 is a critical anti-angiogenic protein that counterbalances the pro-angiogenic activity of various factors, including VEGF, in normal physiology. Solid tumors are characterized by a tortuous vasculature, reduced perfusion, hypoxia, and high interstitial fluid pressure which impairs entry of...

Combined therapy with thrombospondin-1 type I repeats (3TSR) and chemotherapy induces regression and significantly improves survival in a preclinical model of advanced stage epithelial ovarian cancer.

Publication: Journal Article

Russell, Samantha, Mark Duquette, Joyce Liu, Ronny Drapkin, Jack Lawler, and Jim Petrik. 2015. “Combined Therapy With Thrombospondin-1 Type I Repeats (3TSR) and Chemotherapy Induces Regression and Significantly Improves Survival in a Preclinical Model of Advanced Stage Epithelial Ovarian Cancer.”. FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology 29 (2): 576-88.

Masking epistasis between MYC and TGF-β pathways in antiangiogenesis-mediated colon cancer suppression.

Publication: Journal Article

Dews, Michael, Grace S Tan, Stacy Hultine, Pichai Raman, Jaewoo Choi, Elizabeth K Duperret, Jack Lawler, Adam Bass, and Andrei Thomas-Tikhonenko. 2014. “Masking Epistasis Between MYC and TGF-β Pathways in Antiangiogenesis-Mediated Colon Cancer Suppression.”. Journal of the National Cancer Institute 106 (4): dju043.

SCF(β-TRCP) suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2.

Publication: Journal Article

Shaik, Shavali, Carmelo Nucera, Hiroyuki Inuzuka, Daming Gao, Maija Garnaas, Gregory Frechette, Lauren Harris, et al. 2012. “SCF(β-TRCP) Suppresses Angiogenesis and Thyroid Cancer Cell Migration by Promoting Ubiquitination and Destruction of VEGF Receptor 2.”. The Journal of Experimental Medicine 209 (7): 1289-307.

The structure of the Ca²+-binding, glycosylated F-spondin domain of F-spondin - A C2-domain variant in an extracellular matrix protein.

Publication: Journal Article

Tan, Kemin, and Jack Lawler. 2011. “The Structure of the Ca²+-Binding, Glycosylated F-Spondin Domain of F-Spondin - A C2-Domain Variant in an Extracellular Matrix Protein.”. BMC Structural Biology 11: 22.

Thrombospondin 1 inhibits inflammatory lymphangiogenesis by CD36 ligation on monocytes.

Publication: Journal Article

Cursiefen, Claus, Kazuichi Maruyama, Felix Bock, Daniel Saban, Zahra Sadrai, Jack Lawler, Reza Dana, and Sharmila Masli. 2011. “Thrombospondin 1 Inhibits Inflammatory Lymphangiogenesis by CD36 Ligation on Monocytes.”. The Journal of Experimental Medicine 208 (5): 1083-92.

Priming of the vascular endothelial growth factor signaling pathway by thrombospondin-1, CD36, and spleen tyrosine kinase.

Publication: Journal Article

Kazerounian, Shideh, Mark Duquette, Millys A Reyes, James T Lawler, Keli Song, Carole Perruzzi, Luca Primo, et al. 2011. “Priming of the Vascular Endothelial Growth Factor Signaling Pathway by Thrombospondin-1, CD36, and Spleen Tyrosine Kinase.”. Blood 117 (17): 4658-66.

Thrombospondin-1-deficient mice are not protected from bleomycin-induced pulmonary fibrosis.

Publication: Journal Article

Ezzie, Michael E, Melissa G Piper, Christine Montague, Christie A Newland, Judy M Opalek, Chris Baran, Naeem Ali, David Brigstock, Jack Lawler, and Clay B Marsh. 2011. “Thrombospondin-1-Deficient Mice Are Not Protected from Bleomycin-Induced Pulmonary Fibrosis.”. American Journal of Respiratory Cell and Molecular Biology 44 (4): 556-61.

The crystal structure of the signature domain of cartilage oligomeric matrix protein: implications for collagen, glycosaminoglycan and integrin binding.

Publication: Journal Article

Tan, Kemin, Mark Duquette, Andrzej Joachimiak, and Jack Lawler. 2009. “The Crystal Structure of the Signature Domain of Cartilage Oligomeric Matrix Protein: Implications for Collagen, Glycosaminoglycan and Integrin Binding.”. FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology 23 (8): 2490-501.