Physical characterization of platelet thrombospondin.
Margossian, S S, J W Lawler, and H S Slayter. 1981. “Physical Characterization of Platelet Thrombospondin.”. The Journal of Biological Chemistry 256 (14): 7495-500.
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The release of heparin binding peptides from platelet thrombospondin by proteolytic action of thrombin, plasmin and trypsin.
Lawler, J W, and H S Slayter. 1981. “The Release of Heparin Binding Peptides from Platelet Thrombospondin by Proteolytic Action of Thrombin, Plasmin and Trypsin.”. Thrombosis Research 22 (3): 267-79.
Normalizing Tumor Vasculature to Reduce Hypoxia, Enhance Perfusion, and Optimize Therapy Uptake.
Matuszewska, Kathy, Madison Pereira, Duncan Petrik, Jack Lawler, and Jim Petrik. 2021. “Normalizing Tumor Vasculature to Reduce Hypoxia, Enhance Perfusion, and Optimize Therapy Uptake.”. Cancers 13 (17).
Fluvastatin inhibits intimal hyperplasia in wild-type but not Thbs1-null mice.
Desai, Pratik, Alex Helkin, Adeola Odugbesi, Jeff Stein, David Bruch, Jack Lawler, Kristopher G Maier, and Vivian Gahtan. 2017. “Fluvastatin Inhibits Intimal Hyperplasia in Wild-Type But Not Thbs1-Null Mice.”. The Journal of Surgical Research 210: 1-7.
Thrombospondin-1 in a Murine Model of Colorectal Carcinogenesis.
Lopez-Dee, Zenaida P, Sridar Chittur V, Hiral Patel, Aleona Chinikaylo, Brittany Lippert, Bhumi Patel, Jack Lawler, and Linda S Gutierrez. 2015. “Thrombospondin-1 in a Murine Model of Colorectal Carcinogenesis.”. PloS One 10 (10): e0139918.
ABT-510 induces tumor cell apoptosis and inhibits ovarian tumor growth in an orthotopic, syngeneic model of epithelial ovarian cancer.
Greenaway, James, Jack Henkin, Jack Lawler, Roger Moorehead, and Jim Petrik. 2009. “ABT-510 Induces Tumor Cell Apoptosis and Inhibits Ovarian Tumor Growth in an Orthotopic, Syngeneic Model of Epithelial Ovarian Cancer.”. Molecular Cancer Therapeutics 8 (1): 64-74.
The Tyrosine Kinase Inhibitor Lenvatinib Inhibits Anaplastic Thyroid Carcinoma Growth by Targeting Pericytes in the Tumor Microenvironment.
Iesato, Asumi, Stephanie Li, Peter M Sadow, Mohammadreza Abbasian, Ara Nazarian, Jack Lawler, and Carmelo Nucera. 2023. “The Tyrosine Kinase Inhibitor Lenvatinib Inhibits Anaplastic Thyroid Carcinoma Growth by Targeting Pericytes in the Tumor Microenvironment.”. Thyroid : Official Journal of the American Thyroid Association 33 (7): 835-48.
[Sample] Transhumanism and Posthumanism: Future Visions of Humanity.
The course examines the philosophical and technological developments around Transhumanism and Posthumanism. Students will engage with futurist theories, bioethics, and the potential impacts of advancements such as genetic engineering, neuroenhancement, and artificial intelligence. Through...
Thrombospondin Structure
Five members of the TSP gene family have been identified (Fig. 1). TSP-1 and -2 (Subgroup A) are similar in their domain structure and the fact that they form disulfide-linked trimers. By contrast, TSP-3 and -4, and cartilage oligomeric matrix protein (COMP) (Subgroup B) assemble into pentamers. An...
Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia.
Lawler, J, M Sunday, V Thibert, M Duquette, E L George, H Rayburn, and R O Hynes. 1998. “Thrombospondin-1 Is Required for Normal Murine Pulmonary Homeostasis and Its Absence Causes Pneumonia.”. The Journal of Clinical Investigation 101 (5): 982-92.