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David Melville

Person: Research Assistant (2023-2024)

David joined the Machado Lab in March of 2023 after graduating from Harvard College with a Bachelor of Arts degree in Neuroscience at the end of 2022. Previously, David completed his senior thesis in the Stevens Lab at Boston Children’s Hospital, and also spent a summer helping with immunology and...

Andy Chen

Person: Undergraduate Student (Summer 2024)

Perla Alpizar Chacon

Person: Undergraduate Student

Perla joined the lab in August of 2024 to conduct her undergraduate thesis. She is currently pursuing a bachelor in Bioscience's in Tecnologico de Monterrey at Mexico city. Perla has previous research experience working with the Metabolic Disorders Research Unit at the National Institute of Medical...

BIDMC Neurology Faculty Seminar

News: December 16, 2024

Dr. Natalia Machado has been invited to present her recent work with Dr. Luis Costa on, "The potential benefits of deep hypothermia after ischemic stroke" at the Beth Israel Deaconess Medical Center Neurology department Faculty Seminar series this month.

Preoptic EP3R neurons constitute a two-way switch for fever and torpor

Publication: Journal Article

Machado, Natalia L.S., Nicole Lynch, Luis H. A. Costa, David Melville, Hakan Kucukdereli, Satvinder Kaur, Alexander S. Banks, et al. 2025. “Preoptic EP3R Neurons Constitute a Two-Way Switch for Fever and Torpor”. Nature.

AgRP neuron cis-regulatory analysis across hunger states reveals that IRF3 mediates leptin's acute effects

Publication: Journal Article

Heyward, Frankie D., Nan Liu, Christopher L Jacobs, Natalia L.S. Machado, Rachael Ivison, Aykut Uner, Harini Srinivasan, et al. 2024. “AgRP Neuron Cis-Regulatory Analysis across Hunger States Reveals That IRF3 Mediates Leptin’s Acute Effects”. Nature Communication 15 (1): 4646.

A hypothalamic circuit for circadian regulation of corticosterone secretion

Publication: Journal Article

Ramirez-Plascencia, Oscar D., Roberto De Luca, Natalia L.S. Machado, Dominique Eghlidi, Mudasir A. Khanday, Sathyajit S. Bandaru, Francesca Raffin, Nina Vujovic, Elda Arrigoni, and Clifford B. Saper. Submitted. “A Hypothalamic Circuit for Circadian Regulation of Corticosterone Secretion”. Research Square rs.3.rs-4718850 (Submitted).