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Thiamine as adjunctive therapy for diabetic ketoacidosis (DKAT) trial protocol and statistical analysis plan: a prospective, single-centre, double-blind, randomised, placebo-controlled clinical trial in the USA.

Vine, Jacob, Shivani Mehta, Lakshman Balaji, Katherine M Berg, Noa Berlin, Xiaowen Liu, Long Ngo, et al. 2024. “Thiamine As Adjunctive Therapy for Diabetic Ketoacidosis (DKAT) Trial Protocol and Statistical Analysis Plan: A Prospective, Single-Centre, Double-Blind, Randomised, Placebo-Controlled Clinical Trial in the USA.”. BMJ Open 14 (2): e077586.

Program in Placebo Studies

For many years, the placebo effect was considered to be no more than a nuisance variable that needed to be controlled in clinical trials. Only recently have researchers redefined it as the key to understanding the healing that arises from medical ritual, the context of treatment, the patient...