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The Human Sleep and Inflammatory Systems Laboratory at the BIDMC is an international leader in conducting research on the biological basis for the effects of sleep disturbance and deficiency. We utilize intensive physiological monitoring and testing in experimental models of repeated sleep...

The goal of this project is to investigate two processes underlying increased pain vulnerability in the course of repeated exposure to insomnia: (1) Sensitization of the nociceptive system due to a progressive increase of the inflammatory response and (2) Decreased habituation to pain due to a...

The primary goal of this project is to gather preliminary support for the hypothesis that deficient sleep leads to pain amplification through an inflammatory mechanism while the secondary goal is to investigate the potential mechanisms contributing to blood pressure reduction in response to aspirin...

This project gathered preliminary data to test the hypothesis that sleep maintenance insomnia is associated with a stronger activation of stress response systems compared to sleep onset insomnia. Sleep Research Society Foundation [PI: Monika Haack] 10/01/2010 - 09/30/2012

This study investigated whether patients with insomnia have (1) increased pain perception and (2) skill learning impairments compared to healthy controls. Sepracor Inc. [PI: Janet M. Mullington] 6/1/2008 - 5/31/2010

Principal Investigators Janet Mullington, PhD Professor of Neurology, Harvard Medical School jmulling@bidmc.harvard.edu Monika Haack, PhD Associate Professor of Neurology, Harvard Medical School mhaack@bidmc.harvard.edu Huan Yang, PhD Instructor of Neurology, Harvard Medical School hyang7@bidmc...