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Dr. John C. Mathai

Person: Assistant Professor

Dr. Mathai's research interests span across areas as disparate as the biophysics of membrane transport of solutes and gases to the neural control of bladder function. He is currently investigating mechanisms of neural:bladder signaling. Using genetically engineered mice and monitoring calcium...

Alumni

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Name Date Current Position Ali Wu, MD Erandi Velaquez-Miranda, PhD Lian Yu Guo, PhD Reina Kobayashi, DVM

A neurodegeneration checkpoint mediated by REST protects against the onset of Alzheimer's disease.

Publication: Journal Article

Aron, Liviu, Chenxi Qiu, Zhen Kai Ngian, Marianna Liang, Derek Drake, Jaejoon Choi, Marty A Fernandez, et al. 2023. “A Neurodegeneration Checkpoint Mediated by REST Protects Against the Onset of Alzheimer’s Disease.”. Nature Communications 14 (1): 7030.

Minimizing the variables of voiding spot assay for comparison between laboratories.

Publication: Journal Article

Luo, Chuang, Juan Liu, Jiali Yang, Xiang Xie, Weiqun Yu, and Huan Chen. 2023. “Minimizing the Variables of Voiding Spot Assay for Comparison Between Laboratories.”. PeerJ 11: e15420.

Niacinamide May Be Associated with Improved Outcomes in COVID-19-Related Acute Kidney Injury: An Observational Study.

Publication: Journal Article

Raines, Nathan H, Sarju Ganatra, Pitchaphon Nissaisorakarn, Amar Pandit, Alex Morales, Aarti Asnani, Mehrnaz Sadrolashrafi, et al. 2021. “Niacinamide May Be Associated With Improved Outcomes in COVID-19-Related Acute Kidney Injury: An Observational Study.”. Kidney360 2 (1): 33-41.

Novel peptidomimetic compounds attenuate hypoxic-ischemic brain injury in neonatal rats.

Publication: Journal Article

Chen, Xiaodi F, Brynn Kroke, Jun Ni, Christian Munoz, Mark Appleman, Bryce Jacobs, Tuong Tran, et al. 2025. “Novel Peptidomimetic Compounds Attenuate Hypoxic-Ischemic Brain Injury in Neonatal Rats.”. Experimental Neurology 386: 115151.

Yu lab presents recent research at the SUFU Winter meeting

News: February 26, 2025

This years Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction (SUFU) Winter Meeting was held in sunny California at the Westin Rancho Mirage Golf Resort and Spa. Dr Sagar Barge presented his poster entitled; ‘Role of Insulin Signaling in Bladder Smooth Muscle Cell...

Slow development of bladder malfunction parallels spinal cord fiber sprouting and interneurons' loss after spinal cord transection.

Publication: Journal Article

Sartori, Andrea M, Anna-Sophie Hofer, Myriam I Scheuber, Ruslan Rust, Thomas M Kessler, and Martin E Schwab. 2022. “Slow Development of Bladder Malfunction Parallels Spinal Cord Fiber Sprouting and Interneurons’ Loss After Spinal Cord Transection.”. Experimental Neurology 348: 113937.

Yu lab shines light on the role of fat tissue directly regulating bladder function via adipose hormones

News: February 24, 2025

Lower urinary tract symptoms (LUTS) are strongly associated with obesity and type 2 diabetes but the reasons remain unclear. Weiqun Yu and his post-doctoral fellow Dr. Zhaobo Luo (pictured) have just published intriguing data in the journal JCI Insight, demonstrating that the fat hormone adiponectin...

Dr. Zeidel addresses the Dept. of Medicine at the Harvard Club of Boston

News: April 10, 2025

Once a year the Beth Israel Deaconess Medical Center Dept. of Medicine hosts a distinguished visiting Professor of Medicine and has a dinner in their honor. Hosted at the Harvard Club, it brings together physicians, nurses, administrators and researchers to celebrate the Departments achievements and...