The Nath lab works at the interface of genetics, environmental exposures, and chemical biology. We map connections between genes and the human biology they regulate by integrating multi-omics human datasets. We then “retro-translate” these human findings into mechanistic studies using zebrafish models of human disease uniquely developed in our lab, with an eye towards the influence of environmental factors. Leveraging these gene-environment models alongside chemical biology tools, we dissect the molecular underpinnings of disease-relevant pathways that are often modified by environmental exposures. Our overarching goal is to identify actionable disease targets and develop small-molecule therapeutics to correct the dysregulated pathways that cause metabolic diseases and neurodegenerative disorders.
