Nazarian Laboratory

Research

Orthobiologics & Therapeutics

Relaxin-2 as a Novel Therapeutic for the Treatment of Arthrofibrosis
Salt Inducible Kinase Inhibitors as a Therapeutic for Fracture Repair
PR1P as a Therapeutic for Fracture Repair
Cannabinoids as Therapeutic Options for Fracture Repair and Fusion
Functionalized Silk Constructs for Weight-bearing and Non-weight-bearing implants and Osseointegrated Prosthetics

MSK Tissue Mechanics & Mechanobiology

Evaluation of rotator cuff tear initiation and propagation
Hierarchical assessment of rotator cuff tendon mechanics and structure
Mechanobiology of tendon fatigue and tendonapathy
Geno-mechanical understanding of bone repair under normal and pathologic conditions

Diagnostic and Predictive Tools

Assessment of fracture risk in patients with skeletal metastasis
AI-based method for MSK tumor segmentation and classification
AI-based method to predict fragility fracture risk with X-ray imaging
Opportunistic screening of vertebral compression fractures
AI-assisted multi-modal VTE Risk Prediction and prophylaxis prediction

Recent Publications

Nazarian, Ara, Brian D Snyder, David Zurakowski, and Ralph Müller. 2008. “Quantitative Micro-Computed Tomography: A Non-Invasive Method to Assess Equivalent Bone Mineral Density”. Bone 43 (2): 302-11.
Nazarian, Ara, Martin Stauber, David Zurakowski, Brian D Snyder, and Ralph Müller. 2006. “The Interaction of Microstructure and Volume Fraction in Predicting Failure in Cancellous Bone”. Bone 39 (6): 1196-1202.
Nazarian, Ara, John Muller, David Zurakowski, Ralph Müller, and Brian D Snyder. 2007. “Densitometric, Morphometric and Mechanical Distributions in the Human Proximal Femur”. Journal of Biomechanics 40 (11): 2573-79.
Betz, Oliver B, Volker M Betz, Ara Nazarian, Carmencita G Pilapil, Mark S Vrahas, Mary L Bouxsein, Louis C Gerstenfeld, Thomas A Einhorn, and Christopher H Evans. 2006. “Direct Percutaneous Gene Delivery to Enhance Healing of Segmental Bone Defects”. JBJS 88 (2): 355-65.
Nazarian, Ara, Martin Stauber, and Ralph Müller. 2005. “Design and Implementation of a Novel Mechanical Testing System for Cellular Solids”. Journal of Biomedical Materials Research Part B: Applied Biomaterials: An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials 73 (2): 400-411.
Kacena, Melissa A, Ramesh A Shivdasani, Kimberly Wilson, Yougen Xi, Nancy Troiano, Ara Nazarian, Caren M Gundberg, Mary L Bouxsein, Joseph A Lorenzo, and Mark C Horowitz. 2004. “Megakaryocyte-Osteoblast Interaction Revealed in Mice Deficient in Transcription Factors GATA-1 and NF-E2”. Journal of Bone and Mineral Research 19 (4): 652-60.