Publications

2025

Escobar-Domingo MJ, Fanning JE, Posso A, et al. Multimetric Analysis of Online Health Resources for Oncoplastic Breast Surgery Patients.. The Journal of surgical research. 2025;317:208-216. doi:10.1016/j.jss.2025.11.023

INTRODUCTION: Oncoplastic breast surgery (OBS) has gained attention for improving breast cancer patients' satisfaction and quality of life. This study aims to address the readability of online English and Spanish language patient education materials (PEMs) in oncoplastic breast surgery.

METHODS: A de-identified online search using the terms "oncoplastic breast surgery" or "cirugía oncoplástica de seno" was performed. English and Spanish websites were selected and categorized by academic or private centers. Readability scores were generated using established tests: Simple Measure of Gobbledygook (SMOG), Fry Graph, Patient Education Materials Assessment Tool (PEMAT) for Understandability and Actionability, and Cultural Sensitivity and Assessment Tool (CSAT). Fisher's exact tests assessed group differences.

RESULTS: The most common location of origin of online resources was the United States (53%), followed by Europe (23%). The specialties performing OBS included breast surgery (48%), plastic surgery (44%), and obstetric and gynecological surgery (8%). All PEMs failed to meet the recommended readability levels. The average Simplified Measure of Gobbledygook and Spanish Orthographic Length reading level corresponded to that of a university freshman for both academic and private materials, with English websites being more difficult to read than Spanish resources. The average understandability score was slightly higher for academic centers compared to private institutions (63% versus. 61%; P = 0.661). The average actionability score was significantly higher for English websites compared to their Spanish counterparts (35% versus 21%; P < 0.001).

CONCLUSIONS: Patient information found through an online search for OBS is too difficult for the average American adult to read. As patient interest in OBS grows, access to appropriately written educational material is crucial to support informed decision-making, enhance patient satisfaction, reduce decisional regret, and ultimately promote equity in health care.

Escobar-Domingo MJ, Bustos VP, Mahmoud AA, et al. Impact of closed-incision negative pressure therapy in donor-site complications in DIEP flap breast reconstruction: Analysis of 705 patients and 1125 flaps.. Journal of plastic, reconstructive & aesthetic surgery : JPRAS. 2025;105:177-184. doi:10.1016/j.bjps.2025.04.010

BACKGROUND: Closed-incision negative pressure therapy (ciNPT) has been shown to reduce complication rates in breast reconstruction (BR). This study aimed to evaluate postoperative outcomes in deep inferior epigastric perforator (DIEP) donor-site incisions managed with ciNPT compared to standard dressings.

METHODS: We performed a retrospective study of patients ≥18 years who underwent DIEP flap BR from 2015 to 2023. Patients who underwent reconstruction with alternative flaps or converted to transverse rectus abdominus myocutaneous were excluded. Patients were categorized according to the use of ciNPT vs. standard dressings. The unpaired t- and Fisher's Exact tests were used to assess the differences between the groups. Multivariable logistic regression models were used to evaluate postoperative complications.

RESULTS: A total of 705 patients were included, with 68 (9.6%) managed with ciNPT. Patients treated with ciNPT had significantly higher mean body mass index (BMI) (34.0 vs. 28.5 kg/m2; p<0.001) compared to the control group. Higher rates of alcohol use (59.2% vs. 41.2%; p=0.006) and hormonal therapy use (41.3% vs. 17.9%; p<0.001) were found in the standard dressing group. Univariate analyses showed no significant differences in donor-site postoperative outcomes across the groups. However, multivariate logistic regression models demonstrated a reduced likelihood of surgical site infection (OR 0.187; 95% CI 0.045-0.768); p=0.020), and wound dehiscence (OR 0.338; 95% CI 0.155-0.738); p=0.006) among the ciNPT users. Particularly, in patients with BMI >30 kg/m2, ciNPT use (OR 0.282; 95% CI 0.098-0.812; p=0.019) was found to be a significant protective factor against wound complications compared to the standard of care.

CONCLUSIONS: Our findings suggest that ciNPT may improve wound complication rates in DIEP flap donor sites, especially in patients with high BMI. Further research is necessary to elucidate the cost-effectiveness of ciNPT based on the patient risk profiles.

BACKGROUND: Most deaths after outpatient plastic surgery are because of thromboembolic events, particularly pulmonary embolism (PE). The effectiveness of QUAD A deep vein thrombosis (DVT) safety measures after recent policy changes remains undocumented.

OBJECTIVES: The aim of the authors of the study is to assess how adherence to DVT prophylaxis guidelines affects complications and mortality in QUAD A facilities.

METHODS: Using the Patient Safety Data Reporting database, we retrospectively assessed DVT, PE, and mortality rates in adult patients at QUAD A facilities from 2019 to 2023, with subgroup analysis of plastic surgery centers. The authors analyzed demographics and complications relative to facility protocol compliance using descriptive statistics and regression analyses.

RESULTS: The authors identified 3,338,519 surgeries and 247 DVT/PE events. Facility-level deficiencies in DVT/PE prophylaxis ranged from 7.4% to 14.17%; peak deficiencies coincided with the highest complications and mortality. Among DVT/PE patients, 67 underwent plastic surgery (mean age 47.7 years, standard deviation [SD: 11.8]; mean BMI 29.2 kg/m2, [SD: 7.7]); 94% were women. The mean operative time was 220.4 min (SD: 115.9), with 98.5% of procedures under general anesthesia and nearly half of patients (49.3%) hospitalized postoperatively. Liposuction was most commonly associated with complications (38.8%), followed by multiple procedures (23.9%). Within plastic surgery, cosmetic procedures accounted for 73.1% of complications. Statistical analysis showed an association between liposuction and DVT/PE occurrence, with more favorable outcomes for cosmetic procedures (P = .038).

CONCLUSIONS: Following a QUAD A policy change, DVT/PE rates peaked alongside DVT/PE prophylaxis deficiencies. Based on the findings of this study, the authors suggest considering a standardized prophylaxis and preoperative evaluation to reduce morbidity and mortality. Liposuction patients may be at higher risk for these complications.

Mehdizadeh M, Cordero JJ, Mundra LS, et al. Staged Delay Procedure in Deep Inferior Epigastric Artery Perforator Flap Breast Reconstruction in Patients with a History of Liposuction.. Plastic and reconstructive surgery. Published online 2025. doi:10.1097/PRS.0000000000012245

While Deep Inferior Epigastric Artery Perforator (DIEP) flaps are a common option for breast reconstruction, there is limited data on outcomes in patients with a history of abdominal liposuction. Liposuction is one of the most popular aesthetic procedures performed around the world, with over 347,000 procedures performed in the United States in 2023. As the prevalence of both breast cancer and liposuction rises, plastic surgeons increasingly encounter patients interested in autologous breast reconstruction with prior liposuction history. However, the viability of the donor DIEP flap site being potentially compromised by scarring, prior perforator injury, vessel patency issues, and the extent of prior abdominal procedures places patients who have undergone abdominal liposuction at an increased risk of complications due to damaged perforating vessels. A staged delay procedure for DIEP flaps, performed prior to the DIEP flap procedure, may enhance blood flow and vessel caliber through augmentation of choke vessels, offering a potential solution for patients with previous liposuction. In this case series, we present four patients previously deemed unsuitable from outside hospitals for DIEP flap reconstruction due to history of prior liposuction with the majority who successfully underwent autologous breast reconstruction using a staged delay procedure and DIEP flaps. Preoperative imaging with CTA and intraoperative imaging with ICG fluorescence angiography were used. This case series illustrates that staging a delay procedure prior to free flap breast reconstruction can be safely and effectively performed in this patient group, expanding reconstructive possibilities for this growing patient population.

Adebagbo OD, Park JB, Fanning JE, et al. Social media and educational resources in masculinizing top surgery: The effect of age on patient preferences, subjective understanding and readability.. Journal of plastic, reconstructive & aesthetic surgery : JPRAS. 2025;102:54-57. doi:10.1016/j.bjps.2025.01.051

BACKGROUND: As Gender Affirming Top Surgery (GATS) has become more common, educational resources have increased. To ensure healthcare accessibility, a better understanding of preferred platforms and comprehension of these resources is crucial. This study aimed to: determine commonly used resources for GATS patients of varying ages and assess the difficulty of each resource.

METHODS: A public survey seeking perceptions on educational resource utilization related to GATS was administered to gender-diverse individuals. Responses with reported gender identity and age were grouped by age. Online resources were categorized into institutional websites, plastic surgery (PRS) journals, YouTube (YT), internet forums, and educational websites. Perceived difficulty and objective readability of sample text from each category was compared using validated scales. Univariate analyses were performed.

RESULTS: A total of 464 respondents were included, with over half aged 18 to 25, one-third aged 25 to 34%, and 13.8% aged 35 and older. The youngest cohort had lower education, were less likely to have undergone top surgery, and more often favored non-expert resources. When comparing readability, non-expert resources such as YT and internet forums had lower grade levels compared to institutional websites and PRS journals (all p-values ≤ 0.01).

CONCLUSION: Educational preferences and perceived difficulty of resources related to GATS differed significantly by patient age. Overall YouTube and internet forums were popular patient resources and rated as easier to understand by both objective and subjective measures. In order to improve the accessibility of high-quality healthcare information, improving the readability of expert-created resources is essential.

Mahmoud AA, Falcon DJ, Bustos VP, Escobar-Domingo MJ, Lee BT. Application of the Relative Citation Ratio to Assess Common Characteristics of the Highest Impact Articles in Reconstructive Microsurgery.. Archives of plastic surgery. 2025;52(1):46-52. doi:10.1055/a-2380-4278

Background  The purpose of this review is to characterize themes among the five reconstructive microsurgery articles achieving the highest Relative Citation Ratios (RCRs) published in the past 20 years in the top journals. In doing so, researchers may be better informed on how to propose salient research questions to impact the field and understand future directions in plastic surgery. Methods  A cross-sectional study was conducted with articles published in the top three journals based on the Impact Factor: Plastic and Reconstructive Surgery, Journal of Reconstructive Microsurgery, and Annals of Plastic Surgery. A search strategy with controlled vocabulary and keywords was conducted in PubMed to extract all reconstructive microsurgery (RM) articles published between 2002 and 2020. A two-stage screening process to include only RM studies was performed, with a third reviewer moderating discordances. Articles' RCR data were extracted from the National Institutes of Health iCite. The top five articles with the highest RCRs were selected for analysis. Results  We identified three features reflecting educational and clinical trends within RM that might be representative of super-performance in plastic surgery journals. These include (1) relevance to high-yield techniques in RM such as tissue flap procurement, indications, and outcomes, (2) identification of gaps in current knowledge of these topics, and (3) use of media and algorithms to provide clear recommendations. Conclusion  Researchers hoping to have an impactful contribution should pose research questions that address these key themes. The RCR index is a valuable tool to appreciate performance within microsurgery literature and clinical trends within the field.

Schonebaum DI, Li JH, Smith JE, Lee BT, Lin SJ. The influence of cardiovascular disease on duration of admission after DIEP flap breast reconstruction: A retrospective cohort study.. Journal of plastic, reconstructive & aesthetic surgery : JPRAS. 2025;108:129-137. doi:10.1016/j.bjps.2025.07.031

OBJECTIVES: Deep Inferior Epigastric Perforator (DIEP) flaps are a preferred type of autologous breast reconstruction because of their relatively low rate of donor site complications. Comorbidities, such as cardiovascular disease (CVD) and hypertension (HTN), influence the rate of post-operative complications, leading to increased length of stay (LOS). The Nationwide Readmission Database (NRD) compiles readmission and LOS data in the USA. We aim to investigate the relationship between CVD and cardiovascular risk factors and the LOS after DIEP flap.

METHODS: The NRD was queried from 2016 to 2020 using ICD-10 codes for DIEP flaps. The resulting dataset was analyzed for congestive heart failure (CHF), hypertension, obesity and diabetes. Multivariate regression analyses were performed to evaluate the influence of CVD on LOS.

RESULTS: A total of 23,319 cases were identified; the average LOS without comorbidities was 4.15 days. Complicated HTN increased LOS by 1.17 days while uncomplicated HTN, CHF, complicated diabetes, morbid- and moderate obesity all significantly increased the length of stay by 0.09, 0.64, 0.40, 0.29 and 0.24 days, respectively (P<0.05). Out of 20,423 patients, 872 were readmitted within 90 days (4.3%). Main reasons for readmission were infection (83.8%), vascular complications (12.7%) and seroma (8.3%). Flap failure occurred 6 times.

CONCLUSION: Results show that CVD increased the LOS after DIEP flap, with complicated HTN increasing LOS most by 1.17 days. This is clinically relevant due to the rising cost of healthcare and the shortage of healthcare workers.

Fanning JE, Foster L, Manik D, et al. Clarifying the Role of Isotretinoin in Rhinoplasty: A Systematic Review and Analysis of an Emerging Social Media Trend.. Aesthetic plastic surgery. Published online 2025. doi:10.1007/s00266-025-05342-5

PURPOSE: A recent TikTok trend of users reporting nasal size reduction after oral isotretinoin has conflated this acne medication as a nonsurgical rhinoplasty option, termed "Accutane rhinoplasty". We conducted a systematic review of studies reporting outcomes of rhinoplasty and oral isotretinoin and analyzed TikTok reels published under this emerging aesthetic trend.

METHODS: A comprehensive systematic literature search was conducted in December 2024 using the MEDLINE, Web of Science, and EMBASE databases following PRISMA guidelines. Studies reporting outcomes of rhinoplasty patients treated with oral isotretinoin were included. TikTok Scraper extracted details of English-language TikTok reels posted up to September 2024 under three hashtags: #accutanenosejob, #accutanenose, and #accutanenosejobcheck.

RESULTS: Five articles met inclusion criteria. Studies included a median of 24 patients, with isotretinoin administered postoperatively in all studies and preoperatively in two studies. Two of three prospective studies reported positive findings, including lower frequency of facial acne, reduced facial skin thickness, and higher patient satisfaction. Retrospective studies reported mixed findings, including improved nasal skin appearance, increased rhinoplasty complications, and isotretinoin side effects. TikTok hashtags have 68.5 million views, and 100 reels were included for review. Self-reported physicians represented 10% (10/100) of reels and self-reported patients reporting nasal size reduction after isotretinoin represented 90% (90/100) of reels.

CONCLUSIONS: Current evidence on isotretinoin use in rhinoplasty patients is limited, with small sample sizes and mixed findings. While some studies suggest potential benefits in patients with thick nasal skin or severe acne, the long-term effects and safety profile remain unclear. The popularity of "Accutane rhinoplasty" on TikTok contrasts with the scarcity of rigorous clinical data, underscoring the need for further high-quality studies and greater clinician engagement in online discussions.

LEVEL OF EVIDENCE II: Therapeutic study. This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Escobar-Domingo MJ, Rahmani B, Fanning JE, et al. Trends in Minority Representation Among Independent Plastic Surgery Match Applicants: An Analysis of 1000 Applicants Over an 11-Year Period.. Journal of surgical education. 2025;82(2):103388. doi:10.1016/j.jsurg.2024.103388

BACKGROUND: Improving diversity within plastic and reconstructive surgery (PRS) trainees is a crucial step to reduce inequities at the provider level. Trends in minority representation among independent program match applicants are understudied. We analyzed gender, racial, and ethnic demographic trends among independent PRS match applicants.

METHODS: With the approval of the American Council of Educators in Plastic Surgery, the San Francisco Match provided data for the independent PRS match from 2013 to 2023. Trends in the independent PRS match were reviewed, and a Cochran-Armitage test was conducted to evaluate the significance of match trends in minority applicants (Female, Black, Asian, Other Race, Hispanic ethnicity) over time.

RESULTS: A total of 1000 applicants participated in the independent plastic surgery match during the study period, of whom 735 matched. A 31% decrease in the number of independent PRS programs was observed. The match rate decreased from 86% to 60%. Statistical analysis by race (White, Black, Asian, Other) and match outcomes revealed significant differences in racial distributions between applicants and matched participants in 2014 (p = 0.002) and 2018 (p = 0.042). The proportion of female applicants and Hispanic applicants correlated yearly to the number of matched females and Hispanics, respectively (p > 0.05). Cochran-Armitage tests showed a significant increase in match trends among female participants over time (p = 0.004).

CONCLUSIONS: We show a significant increase in female representation in the independent PRS match in the last decade. However, representation of racial and ethnic minorities has shown minimal change over the years. Ongoing efforts are needed to identify barriers and reduce inequities.

Posso AN, Bloom J, Tobin M, et al. Saving millions: The economic impact of switching to waterless surgical hand scrubs in plastic and reconstructive surgery.. Journal of plastic, reconstructive & aesthetic surgery : JPRAS. 2025;107:148-150. doi:10.1016/j.bjps.2025.06.027

BACKGROUND: Alcohol-based surgical hand scrubs are a safe, environmentally friendly, and cost-effective alternative to traditional water-based hand antisepsis, supported by the World Health Organization (WHO). These advantages make alcohol-based hand scrubs ideal for various plastic and reconstructive surgery settings. This study evaluates the potential financial savings of transitioning to alcohol-based surgical scrubs within a division of plastic and reconstructive surgery.

METHODS: Data was collected from a division of plastic and reconstructive surgery at a single institution. Water consumption for traditional surgical hand scrub was measured according to WHO guidelines. Water costs were calculated based on the Boston Water and Sewer Commission rates. The costs of alcohol solution and impregnated brushes were obtained from the hospital's perioperative services. Annual surgical volume data were used to estimate water consumption and consumable costs. Time savings were calculated based on WHO protocols and converted into cost savings.

RESULTS: The average water consumption per scrub was 7.62 L, with an average of 36.17 L used per surgery. If every plastic surgery procedure used traditional wet scrubs, the annual water consumption would be 87,233.76 L. The cost of water per scrub was $0.05. The consumable cost per scrub was $0.20 for alcohol-based scrubs and $0.52 for wet scrubs. Annually, transitioning to alcohol-based scrubs would save $3090.96 in consumable costs. Adopting waterless scrubs and decreasing scrub time could result in savings of $1316,445.48 annually in our division.

CONCLUSION: Transitioning to alcohol-based surgical hand scrub in plastic and reconstructive surgery may provide significant environmental and economic benefits.