Our lab possesses a unique capability to utilize tissues from organ donors, supported by the newly established BIDMC/New England Donor Services (NEDS) hospital-based Donor Care and Recovery Center. By integrating these tissues with differentiated stem cells, we develop multicellular 3D organoids that faithfully replicate the cellular microenvironment and components of native organs. This innovative approach has the potential to revolutionize regenerative medicine and drug discovery by overcoming the limitations of traditional in vitro organoid models, which often lack the complexity and fidelity of real tissues. Additionally, our ability to generate patient-specific human induced pluripotent stem cells (hiPSCs) from donor tissue positions our Center as a leader in personalized medicine, enabling precise disease modeling and the identification of more effective therapeutic strategies.