About
Location
Wu Laboratory is part of the Cancer Center at Beth Israel Deaconess Medical Center and the Department of Medicine at Harvard Medical School. We are also affiliated with the Broad Institute of MIT and Harvard and Dana-Farber Cancer Institute. Our lab is located on the 4th floor of the Center for Life Science Building in the heart of Boston's Longwood Medical and Academic Area, where Boston Children's Hospital, Brigham and Women's Hospital, Wyss Institute and Merck Research Laboratories are located.
Approaches
We use and develop integrative, cross-disciplinary strategies that unite experimental and computational innovation
Epigenomics
We use a suite of epigenomic technologies, including ATAC-seq, CUT&Tag, and DNA methylation sequencing, to decode chromatin landscapes, protein–DNA interactions, and epigenetic states at single-base resolution. Our work integrates both Illumina short-read and Oxford Nanopore long-read sequencing platforms to achieve a comprehensive view of the genome’s regulatory architecture.
DNA damage
We are fascinated by the interplay between epigenetic regulation and DNA damage repair. To explore this connection, we employ a powerful toolkit that combines high-resolution imaging and sequencing–based assays to precisely quantify and map DNA damage across the genome.
Drug Screening
We collaborate with the Broad Institute’s DepMap project to uncover the molecular basis of drug sensitivity and resistance across the Cancer Cell Line Encyclopedia (CCLE). Through integrative functional genomics and drug-response profiling, we identify cell lines and targets that dictate how cancer cells respond or adapt to therapeutic pressure.
Computational analysis
We leverage high-performance computing clusters and cloud-based analytical platforms to mine vast consortium-scale datasets, enabling the discovery of novel molecular targets and mechanistic insights that drive cancer progression and therapeutic response.
Funding
We are supported by institutional resources and competitive grants from the National Institutes of Health (NIH).
