The Precision RNA Medicine (PRM) Core is a state-of-the-art informatics, delivery, and preclinical facility dedicated to precision medicine at Beth Israel Deaconess Medical Center (BIDMC) and Harvard Medical School (HMS). The Core is directed by Associate Professor Win Hide, and is co-directed by Professor Frank Slack, Director of the Harvard Medical School Initiative for RNA Medicine (HIRM).
The HIRM was established in 2014 and is hosted by the BIDMC Cancer Center. The HIRM brings together leading investigators in the field to accelerate investigations into how non-coding RNA functions and how these insights can be used to develop new therapies. The PRM Core was subsequently established as part of the HIRM in 2017 to support coding and non-coding RNAs assays for researchers affiliated with BIDMC and HMS, as well as biomedical research activities in not-for-profit research institutes, academia and industry.
The PRM Core is Made Up of 3 Independent Units — Bioinformatics, Delivery, and Detection.
(Directors: Dr. Win Hide and Dr. Ioannis Vlachos)
(RRID: SCR_025859)
Provides both simple and complex studies, aimed at uncovering insights into the non-coding genome and prioritizing coding and non-coding RNAs & variants.
(Director: Dr. Frank Slack)
(RRID: SCR_024862)
Performs delivery of RNA via nanoparticle packaging, both in vitro and in vivo, using the NanoAssemblr Spark, Benchtop, and Blaze systems from Precision NanoSystems.
(Director: Dr. Jan Heng)
(RRID: SCR_024819)
Provides a sensitive, multiplex microRNA detection platform utilizing qPCR and MIRXES technology. The assay panels can simultaneously detect up to 376 miRNAs on a single 384-well plate. Additionally, discounted next-generation sequencing services via a third-party vendor are offered to BIDMC researchers.