Who We Are
We are a team of computational biologists and analysts, dedicated to equipping wet-lab scientists with the expertise needed to answer their most questions. Empowering researchers from within the Beth Israel community and the larger surrounding area, our core supports projects at each stage, from experimental design to workflow development and sequencing data interpretation.
What We Do
We specialize in bioinformatics investigations ranging from focused studies to complex multi-layered projects, aimed at interrogating the coding and non-coding genome. Our unit prioritizes uncovering various RNA biotypes and regulatory variants, equipping investigators with target identification and translational genomic capabilities.
We provide a broad range of analytical services and grant development support. We analyze high throughput sequencing data, including bulk and snRNA seq, coding and noncoding RNA and genomics. We also provide consultation and support for coding and non-coding RNA research.
Rates
| Workflows | Pricing | Description |
|---|---|---|
| Standard Analyses | $150 / hour |
|
| Advanced Analyses | $200 / hour |
|
How To Engage
- Submit a request
Describe your project and goals using our consultation form. You will also be prompted to create an account on iLabs so that project progress can be tracked and billed effectively.
- 48-hour response
We get back to you within 48 hours to discuss the details of your project, an estimated timeline for results, and how those results will be presented.
- Scoped Analysis
We carry out the agreed analysis and deliver results with clear documentation and support. Results are typically presented as a clean, professional R-Markdown report.
For more information about our services, please reach out:
Directors:
Dr. Win Hide
Dr. Ioannis Vlachos
Bioinformaticians:
Leinal Sejour
PUBLICATIONS
LncRNA Dlx4os drives malignant transformation and phenotype switching in melanoma.
Ayub ALP, Tonin BCB, Azevedo H, Jordão PHF, Saxena T, Sejour L, Nsengimana J, Vlachos I, Reis EM, Slack FJ, Jasiulionis MG
Epigenetics • 2026 Dec;21(1):2641924 • doi: 10.1080/15592294.2026.2641924 • Epub 2026 Mar 19 • PMID: 41855479
Long non-coding RNA triplex-dependent regulation of melanoma gene networks.
Shah K, Anastasakou E, Sejour L, Guseva S, Rauchet C, Wert-Lamas L, Calandrelli R, Distel R, Zhong S, Vlachos I, Novina CD
NAR Genomics and Bioinformatics • 2026 Jun 27;8(3):lqag067 • doi: 10.1093/nargab/lqag067 • PMID: 42369015
IDH1-R132H enhances oncolytic HSV-1 therapy by facilitating viral entry and immune activation in glioma.
Panagioti E, Kelley HJ, Ling AL, Sejour L, Saini S, Goins WF, Roberts D, Sotiriou S, Iorgulescu JB, Dixon KO, Yaffe MB, Vlachos IS, Castro MG, Lawler SE, Freeman GJ, Kuchroo VK, Chiocca EA, Cook CH
Nature Communications • 2026 Jun 17 • doi: 10.1038/s41467-026-73974-5 • Online ahead of print • PMID: 42310302
A microRNA atlas of the human prefrontal cortex across the adult lifespan.
Valenzuela-Arzeta IE, Yeganeh PN, Rai A, Banahan J, Iatrou A, Sejour L, Uyemura M, Solomon IH, Daskalakis NP, Vlachos I, Hide W, Slack FJ, Mavrikaki M
bioRxiv [Preprint] • 2026 May 28:2026.05.27.728239 • doi: 10.64898/2026.05.27.728239 • PMID: 42244746
LncRNA SLNCR phenocopies the E2F1 DNA binding site to promote melanoma progression.
Shah K, Anastasakou E, Sejour L, Wang Y, Wert-Lamas L, Rauchet C, Studer S, Goller S, Distel RJ, Marasco W, Perera L, Vlachos IS, Novina CD
Cell Reports • 2025 May 27;44(5):115608 • doi: 10.1016/j.celrep.2025.115608 • Epub 2025 Apr 23 • PMID: 40279246
Inhibition of Cyp1a Protects Mice against Anthracycline Cardiomyopathy.
Liu J, Curtin C, Lall R, Lane S, Wieke J, Ariza A, Sejour L, Vlachos I, Zordoky BN, Peterson RT, Asnani A
bioRxiv [Preprint] • 2024 Apr 11:2024.04.10.588915 • doi: 10.1101/2024.04.10.588915 • PMID: 38645084
Tissue-Specific Human Extracellular Matrix Scaffolds Promote Pancreatic Tumour Progression and Chemotherapy Resistance.
Al-Akkad W, Acedo P, Vilia MG, Frenguelli L, Ney A, Rodriguez-Hernandez I, Labib PL, Tamburrino D, Spoletini G, Hall AR, Canestrari S, Osnato A, Garcia-Bernardo J, Sejour L, Vassileva V, Vlachos IS, Fusai G, Luong TV, Whittaker SR, Pereira SP, Vallier L, Pinzani M, Rombouts K, Mazza G
Cells • 2022 Nov 17;11(22):3652 • doi: 10.3390/cells11223652 • PMID: 36429078
Testimonials
"Our collaboration with the BIDMC Precision RNA Medicine Core was essential to advancing our understanding of how the lncRNA SLNCR drives melanoma progression through binding directly to transcription factors and DNA. The core performed bioinformatic analysis including RNA-seq, transcription factor enrichment, survival curves, and RNA-DNA triplex target site identification, enabling us to uncover key mechanisms reported in our publications. Their combination of technical expertise and thoughtful scientific collaboration greatly enhanced the quality and impact of our work."
- Kushani Shah, Ph. D
"The Mavrikaki lab at BIDMC is interested in the molecular mechanisms of aging in the human brain, and in that context, we have had the opportunity to work closely with the BIDMC Bioinformatics core. They possess unique expertise in analyzing small RNA sequencing datasets, and their well-established pipelines were vital to the success of our recent project. Furthermore, the team has been incredibly responsive and easy to communicate with, even when working under tight, short-notice deadlines. Their support was instrumental in helping us reach our publication goals."
- Maria Mavrikaki, Ph. D
"The BIDMC Transcriptomics Core provided exceptional bioinformatics expertise that greatly enhanced our study. Their analytical rigor, responsiveness, and collaborative approach were invaluable to our project and played a key role in strengthening our manuscript. I highly recommend working with their team."
- Eleni Panagioti, Ph. D
