Help us advance women's health research by participating in the SADIE research study! We are investigating how pregnenolone affects the brain in perimenopausal women who are experiencing depression. We are doing this by giving women pregnenolone that is available as an oral over-the-counter dietary supplement in the US. It has been shown to have a potential therapeutic benefit for depression in a previous clinical trial involving treatment with pregnenolone or placebo.
If you are:
- between ages 40-60
- going through, or have recently gone through menopause
- experiencing depressive symptoms
Please complete the survey linked here to help determine if you might be eligible to participate in this study. A research coordinator will be in touch with you if you are eligible for further screening.
Participation includes:
- attendance of four study visits
- taking an over-the-counter supplement two times a day for four weeks
- providing blood and urine samples
- having two optional MRI scans
For more information, please contact the study coordinator at bidmc-sadiestudy@bidmc.harvard.edu or call us at 617-975-8710.
Principal Investigator: Hadine Joffe, MD MSc
