Study of Fatigue in Patients on Palbociclib
Completed Accrual
This observational study of patients with metastatic breast cancer aims to investigate the development and course of fatigue during the first 6 months of palbociclib combination therapy. We also will examine the patient perspective on fatigue and other effects of palbociclib combination therapy on quality of life.
This study is being conducted at Dana Farber Cancer Institute and Brigham and Women’s Hospital.
Related Publications:
Manuscript in progress
Predicting Hot Flash And Quality Of Life Response To Breast Cancer Therapies
Completed Accrual
The goal of this observational study is to identify psychological traits, sleep patterns, and tamoxifen metabolism/genetic characteristics that predict the development of hot flashes and decline in quality of life among breast cancer patients on endocrine therapy.
Women with Stage 1 or 2 breast cancer who were starting tamoxifen or aromatase inhibitors were enrolled. Study participation included completing surveys four times over 7 months and brief daily hot flash diaries for the first 8 weeks on hormone therapies, as well as the option to wear a sleep monitor for one week at 3 time points.
This study was conducted at Dana Farber Cancer Institute and Brigham and Women’s Hospital.
Related Publications:
Yusufov M, Nathan M, Wiley A, Russell J, Partridge A, Joffe H. Predictors of increased risk for early treatment non-adherence to oral anti-estrogen therapies in early-stage breast cancer patients. Breast Cancer Res Treat. 2021 Jan;185(1):53-62. doi: 10.1007/s10549-020-05920-y. Epub 2020 Sep 12. PMID: 32918659.
Testing The Feasibility Of A Remotely Administered Behavioral Intervention To Improve Quality Of Life Among Erly Stage Breast Cancer Patients
Completed Accrual
As an optional nested cohort within the observational study described above, this study is investigating whether a remotely administered cognitive behavioral intervention is a feasible method of addressing possible psychological predictors of quality of life decline.
Related Publications:
Manuscript in progress
Phase IIB Double-Blind Placebo Controlled Trial Of Naltrexone For Treatment-Emergent Fatigue In Patients Radiation For Breast Cancer
Monitoring Phase Completed Accrual; Intervention Phase Terminated
- This project investigates the incidence and predictors of radiotherapy-related fatigue in breast cancer patients.
