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Musculoskeletal health in aging, osteoporosis and diabetes
Our research focuses on understanding musculoskeletal health, particularly in the context of aging, osteoporosis, diabetes (T1D and T2D). We employ advanced non-invasive and in vivo quantitative imaging techniques, along with ex vivo bone specimen analyses and preclinical studies, to assess bone and...
Mechanical Testing
Although imaging is often used as a surrogate to evaluate bone fragility, direct measurements of mechanical strength are undoubtedly the gold standard for providing information about the mechanical integrity of bone. Our lab offers a variety of mechanical testing options for measuring the mechanical...
Musculoskeletal health in Indigenous populations
Our team collaborates on the Tsimane Health and Life History Project to investigate how lifestyle, physical activity, and diet influence musculoskeletal health across the lifespan. Studying the Tsimane—an Indigenous forager-horticulturalist population in the Bolivian Amazon—provides unique insights...
Contributions of Bone Microarchitecture to Skeletal Fragility in Adults with Longstanding Type 1 Diabetes.
Marion, Lipi A, Fjola Johannesdottir, Crystabella E Nevarez, Jane Y Wang, Grace H Jung, Richard Z Decurtis, Andria I Fremaint, et al. 2026. “Contributions of Bone Microarchitecture to Skeletal Fragility in Adults With Longstanding Type 1 Diabetes.”. Journal of Bone and Mineral Research : The Official Journal of the American Society for Bone and Mineral Research.
Prolonging parathyroid hormone analog action in vitro and in vivo through peptide lipidation.
Höppner, Jakob, Hiroshi Noda, Anju Krishnan Anitha, Ross W Cheloha, Thomas Dean, Michael Bruce, Daniel J Brooks, et al. 2025. “Prolonging Parathyroid Hormone Analog Action in Vitro and in Vivo through Peptide Lipidation.”. Nature Communications 16 (1): 4487.
Model for Musculoskeletal Injury Risk Factors Among US Army Basic Combat Trainees.
Foulis, Stephen A, Susan P Proctor, Barry A Spiering, Leila A Walker, Katelyn Guerriere Aaron, Colleen M Castellani, Ian M Hussian, et al. 2025. “Model for Musculoskeletal Injury Risk Factors Among US Army Basic Combat Trainees.”. JAMA Network Open 8 (6): e2513177.
The relationship between fall risk, trochanteric soft tissue thickness, and hip fracture risk in older adults.
Johannesdottir, Fjola, Thor Aspelund, Sarah Mahar, Sigurdur Sigurdsson, Vilmundur Gudnason, and Mary L Bouxsein. 2025. “The Relationship Between Fall Risk, Trochanteric Soft Tissue Thickness, and Hip Fracture Risk in Older Adults.”. Journal of Bone and Mineral Research : The Official Journal of the American Society for Bone and Mineral Research.
Collaborators
We recognize the value of collaborations and are proud of our many collaborators, both current and past. Collaboration is at the heart of scientific progress, and we are happy to highlight some of our collaborations below: San Francisco Coordinating Center, The Osteoporotic Fractures in Men (MrOS)...