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The Lawler lab has studied the structure and function of the members of the TSP gene family for more than 50 years. We have focused on the role of TSP-1 in the tumor microenvironment. This research has informed the development of a new cancer therapeutic that is currently being evaluated in murine...

News + Updates

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Our studies on the effects of Fc3TSR in a preclinical model of pancreatic cancer were recently reported at the September AACR meeting in Boston. Abstract A040: Assessing the ability of Fc3TSR to remodel the tumor microenvironment and enhance efficacy of immunotherapeutics and chemotherapy in a...

Relationship between margin distance and local recurrence among patients undergoing wedge resection for small (≤2 cm) non-small cell lung cancer.

Publication: Journal Article

Mohiuddin, Kamran, Sebastien Haneuse, Tamar Sofer, Ritu Gill, Michael T Jaklitsch, Yolonda L Colson, Jon Wee, et al. 2014. “Relationship Between Margin Distance and Local Recurrence Among Patients Undergoing Wedge Resection for Small (≤2 Cm) Non-Small Cell Lung Cancer.”. The Journal of Thoracic and Cardiovascular Surgery 147 (4): 1169-75; discussion 1175.

A-clustering: a novel method for the detection of co-regulated methylation regions, and regions associated with exposure.

Publication: Journal Article

Sofer, Tamar, Elizabeth D Schifano, Jane A Hoppin, Lifang Hou, and Andrea A Baccarelli. 2013. “A-Clustering: a Novel Method for the Detection of Co-Regulated Methylation Regions, and Regions Associated With Exposure.”. Bioinformatics (Oxford, England) 29 (22): 2884-91.

Genome-wide association study of iron traits and relation to diabetes in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL): potential genomic intersection of iron and glucose regulation?

Publication: Journal Article

Raffield, Laura M, Tin Louie, Tamar Sofer, Deepti Jain, Eli Ipp, Kent D Taylor, George J Papanicolaou, et al. 2017. “Genome-Wide Association Study of Iron Traits and Relation to Diabetes in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL): Potential Genomic Intersection of Iron and Glucose Regulation?”. Human Molecular Genetics 26 (10): 1966-78.

A powerful statistical framework for generalization testing in GWAS, with application to the HCHS/SOL.

Publication: Journal Article

Sofer, Tamar, Ruth Heller, Marina Bogomolov, Christy L Avery, Mariaelisa Graff, Kari E North, Alex P Reiner, et al. 2017. “A Powerful Statistical Framework for Generalization Testing in GWAS, With Application to the HCHS/SOL.”. Genetic Epidemiology 41 (3): 251-58.

CONTROL FUNCTION ASSISTED IPW ESTIMATION WITH A SECONDARY OUTCOME IN CASE-CONTROL STUDIES.

Publication: Journal Article

Sofer, Tamar, Marilyn C Cornelis, Peter Kraft, and Eric J Tchetgen Tchetgen. 2017. “CONTROL FUNCTION ASSISTED IPW ESTIMATION WITH A SECONDARY OUTCOME IN CASE-CONTROL STUDIES.”. Statistica Sinica 27 (2): 785-804.

Genome-wide association study of heart rate and its variability in Hispanic/Latino cohorts.

Publication: Journal Article

Kerr, Kathleen F, Christy L Avery, Henry J Lin, Laura M Raffield, Qian S Zhang, Brian L Browning, Sharon R Browning, et al. 2017. “Genome-Wide Association Study of Heart Rate and Its Variability in Hispanic/Latino Cohorts.”. Heart Rhythm 14 (11): 1675-84.

Correction: Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations.

Publication: Journal Article

Liang, Jingjing, Thu H Le, Digna R Velez Edwards, Bamidele O Tayo, Kyle J Gaulton, Jennifer A Smith, Yingchang Lu, et al. 2018. “Correction: Single-Trait and Multi-Trait Genome-Wide Association Analyses Identify Novel Loci for Blood Pressure in African-Ancestry Populations.”. PLoS Genetics 14 (5): e1007345.

Pharmacogenomics study of thiazide diuretics and QT interval in multi-ethnic populations: the cohorts for heart and aging research in genomic epidemiology.

Publication: Journal Article

Seyerle, A A, C M Sitlani, R Noordam, S M Gogarten, J Li, X Li, D S Evans, et al. 2018. “Pharmacogenomics Study of Thiazide Diuretics and QT Interval in Multi-Ethnic Populations: The Cohorts for Heart and Aging Research in Genomic Epidemiology.”. The Pharmacogenomics Journal 18 (2): 215-26.