In our laboratory, we investigate the finely tuned neural control mechanisms that govern voiding and continence in the bladder. Our aims are to map the circuits, create neural atlases of neuron sub-populations and then determine what each type of neuron does.
from Human Bladder Tissue and Characterizing
Genetic Knockouts in Mice.
Our investigators are performing basic research on the following: overactive bladder, urinary retention, diabetic bladder dysfunction, ketamine cystitis and brain injury (from dementia to Alzheimers to Parkinsons, to head trauma).
We use mice to perform pre-clinical research designed to:
- shed light on normal bladder functions,
- define the important pathways which when perturbed, cause symptoms,
- identify which parts of the bladder and which cells are affected,
- thereby leading to new drug targets,
- and new therapeutic approaches!
