About Us

Welcome to the Zeidel Lab!

Disorders of voiding, including incontinence, overactive bladder, bladder pain and lower urinary tract symptoms, as reported in patients, increase rapidly as people age, and affect more than 70% of people over the age of 40 (Coyne et al. (2009) BJU Int 104:352). Our lab focuses on fundamental research questions in animal models that attempt to understand the neural circuitry that controls how, when we urinate, and also to modeling urinary tract disease so that better understanding can lead to better treatments. We use state-of-the-art techniques in next generation single nuclei RNA sequencing, opto- and chemo-genetics, neural tracing, fMRI, Cre-recombinase reporter mice, electrophysiology and in vivo physiological measurements.

Regards,
Mark L. Zeidel, MD 
Herrman L. Blumgart Professor of Medicine
Harvard Medical School 
Chair, Department of Medicine
Beth Israel Deaconess Medical Center