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Autonomic Control of Kidney Function

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Prior work by others suggests that renal nerves arise from several neuron subpopulations in sympathetic ganglia. It is possible that these specific subpopulations of neurons, as well as the CNS circuits that innervate them selectively control tubular transport, glomerular filtration rate or renin...

Funding

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Zeidel Lab

Zeidel Lab, BIDMC, Harvard Medical School, Dr. Mark Zeidel, Mark Zeidel Lab, Incontinence, Overactive Bladder, Bladder Pain and Lower Urinary Tract, Kidney, Kidney Research in BIDMC, Bladder Research in BIDMC, Basic Cellular Mechanisms Underlying Diseases of the Lower Urinary Tract, Benign Urology Research, Warren Hill, Bryce MacIver, John Mathai, Weiqun Yu

Single Cell RNA-seq Identification of Neuron Populations Controlling Bladder Function

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Modern transgenic “tools” enable specific neuron populations to be mapped, monitored, and manipulated in vivo. While these approaches represent an enormous advance, their application requires knowledge of specific transcriptional markers for distinguishing the neurons of interest from their...

Bladder Projects

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In our laboratory, we investigate the finely tuned neural control mechanisms that govern voiding and continence in the bladder. Our aims are to map the circuits, create neural atlases of neuron sub-populations and then determine what each type of neuron does. Our investigators are performing basic...