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Delivery Unit
We can perform delivery of RNA via nanoparticle packaging both in vitro and in vivo using NanoAssemblr technology from Precision NanoSystems. Using an off-the-shelf lipid (Genvoy-ILM), the core can deliver siRNAs, miRNAs, mRNA, and more. Additionally, clients can use their own lipids and test...
Aaron Grant
Imaging with Hyperpolarized Tertiary-butyl Alcohol
Perdeuterated [2- 13C]tertiary-butyl alcohol (TBA) is a hyperpolarized MRI perfusion tracer that diffuses freely through biological membranes, including the blood-brain barrier. Owing to its large distribution volume, it has a long residence time in tissue and can be imaged with high sensitivity...
Team
A comprehensive review of electrophysiological techniques in amyotrophic lateral sclerosis research.
Ren, Keyuan, Qinglong Wang, Douglas Jiang, Ethan Liu, Julie Alsmaan, Rui Jiang, Seward B Rutkove, and Feng Tian. 2024. “A Comprehensive Review of Electrophysiological Techniques in Amyotrophic Lateral Sclerosis Research.”. Frontiers in Cellular Neuroscience 18: 1435619.
Probe the gut, protect the brain?
Dr. Trisha Pasricha and her laboratory at the BIDMC Institute for Gut-Brain Research were featured in the December Findings feature of the Harvard Gazette. The profile highlights the work examining the possibly gut-first origins of Parkinson's disease. “Parkinson’s disease is very well known and...
Associations of PFAS concentrations during pregnancy and midlife with bone health in midlife: Cross-sectional and prospective findings from Project Viva.
Lin, Pi-I Debby, Andres Cardenas, Lisa B Rokoff, Sheryl L Rifas-Shiman, Mingyu Zhang, Julianne Botelho, Antonia M Calafat, et al. 2024. “Associations of PFAS Concentrations During Pregnancy and Midlife With Bone Health in Midlife: Cross-Sectional and Prospective Findings from Project Viva.”. Environment International 194: 109177.
Dietary plant-to-animal protein ratio and risk of cardiovascular disease in 3 prospective cohorts.
Glenn, Andrea J, Fenglei Wang, Anne-Julie Tessier, JoAnn E Manson, Eric B Rimm, Kenneth J Mukamal, Qi Sun, et al. 2024. “Dietary Plant-to-Animal Protein Ratio and Risk of Cardiovascular Disease in 3 Prospective Cohorts.”. The American Journal of Clinical Nutrition 120 (6): 1373-86.
Diagnostic scope: the AI can't see what the mind doesn't know.
Weissman, Gary E, Laura Zwaan, and Sigall K Bell. 2024. “Diagnostic Scope: The AI Can’t See What the Mind Doesn’t Know.”. Diagnosis (Berlin, Germany).