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Reply: Alcohol-induced extracellular ASC specks perpetuate liver inflammation and damage in alcohol-associated hepatitis even after alcohol cessation.

Publication: Journal Article

Ribeiro, Marcelle de Carvalho, Mrigya Babuta, and Gyongyi Szabo. 2024. “Reply: Alcohol-Induced Extracellular ASC Specks Perpetuate Liver Inflammation and Damage in Alcohol-Associated Hepatitis Even After Alcohol Cessation.”. Hepatology (Baltimore, Md.) 79 (2): E28-E29.

IRF3 regulates neuroinflammatory responses and the expression of genes associated with Alzheimer's disease.

Publication: Journal Article

Joshi, Radhika, Veronika Brezani, Gabrielle M Mey, Sergi Guixé-Muntet, Martí Ortega-Ribera, Yuan Zhuang, Adam Zivny, Sebastian Werneburg, Jordi Gracia-Sancho, and Gyongyi Szabo. 2024. “IRF3 Regulates Neuroinflammatory Responses and the Expression of Genes Associated With Alzheimer’s Disease.”. BioRxiv : The Preprint Server for Biology.

Randomized trial of anakinra plus zinc vs. prednisone for severe alcohol-associated hepatitis.

Publication: Journal Article

Gawrieh, Samer, Srinivasan Dasarathy, Wanzhu Tu, Patrick S Kamath, Naga P Chalasani, Craig J McClain, Ramon Bataller, et al. 2024. “Randomized Trial of Anakinra Plus Zinc Vs. Prednisone for Severe Alcohol-Associated Hepatitis.”. Journal of Hepatology 80 (5): 684-93.

Combined Insults of a MASH Diet and Alcohol Binges Activate Intercellular Communication and Neutrophil Recruitment via the NLRP3-IL-1β Axis in the Liver.

Publication: Journal Article

Babuta, Mrigya, Prashanth Thevkar Nagesh, Aditi Ashish Datta, Victoria Remotti, Yuan Zhuang, Jeeval Mehta, Francesca Lami, Yanbo Wang, and Gyongyi Szabo. 2024. “Combined Insults of a MASH Diet and Alcohol Binges Activate Intercellular Communication and Neutrophil Recruitment via the NLRP3-IL-1β Axis in the Liver.”. Cells 13 (11).

Reply: How does bile acid-induced IRF3 phosphorylation mediate cholestatic liver and kidney injury?-More needs to be known.

Publication: Journal Article

Zhuang, Yuan, and Gyongyi Szabo. 2024. “Reply: How Does Bile Acid-Induced IRF3 Phosphorylation Mediate Cholestatic Liver and Kidney Injury?-More Needs to Be Known.”. Hepatology (Baltimore, Md.) 80 (1): E2-E3.

Acute kidney injury in severe alcohol-associated hepatitis treated with anakinra plus zinc or prednisone.

Publication: Journal Article

Patidar, Kavish R, Wanzhu Tu, Thomas G Cotter, Douglas A Simonetto, Amon Asgharpour, Muhammad Y Jan, Qing Tang, et al. 2024. “Acute Kidney Injury in Severe Alcohol-Associated Hepatitis Treated With Anakinra Plus Zinc or Prednisone.”. Hepatology (Baltimore, Md.).

In vivo Bruton's tyrosine kinase inhibition attenuates alcohol-associated liver disease by regulating CD84-mediated granulopoiesis.

Publication: Journal Article

Nagesh, Prashanth Thevkar, Yeonhee Cho, Yuan Zhuang, Mrigya Babuta, Martí Ortega-Ribera, Radhika Joshi, Veronika Brezani, et al. 2024. “In Vivo Bruton’s Tyrosine Kinase Inhibition Attenuates Alcohol-Associated Liver Disease by Regulating CD84-Mediated Granulopoiesis.”. Science Translational Medicine 16 (759): eadg1915.

Associate - Clinical Research / Research

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Inflammation in NASH

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Danger signals and pathways of macrophage activation in NASH Inflammatory cell activation drives diverse cellular programming in steatohepatitis. Our studies revealed that activation of the multiprotein complex, inflammasome, contributes to non-alcoholic steatohepatitis (NASH) involving the NLRP3...

NIH/NIAAA - Innate Immune Signaling in Alcoholic Liver Disease – Alzheimer’s Disease Supplement:

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Experiments proposed in this supplement will explore novel signaling molecules in alcohol-induced neuroinflammation and interactions between alcohol use and key pathways in the biology of neuroinflammation and AD dementia. Our studies will reveal new potential therapeutic targets in the dual insult...