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Name Date Current Position Ali Wu, MD Erandi Velaquez-Miranda, PhD Lian Yu Guo, PhD Reina Kobayashi, DVM

Results - Obtained Under Urethane Anesthesia Regions that show activation during CMG peak include the Pontine Micturition Center (PMC), the Periaqueductal Gray (PAG) and the Hypothalamus. The PMC is a small center in the hindbrain that we now know activates bladder contractions, whereas the PAG...

Modern transgenic “tools” enable specific neuron populations to be mapped, monitored, and manipulated in vivo. While these approaches represent an enormous advance, their application requires knowledge of specific transcriptional markers for distinguishing the neurons of interest from their...

In our laboratory, we investigate the finely tuned neural control mechanisms that govern voiding and continence in the bladder. Our aims are to map the circuits, create neural atlases of neuron sub-populations and then determine what each type of neuron does. Our investigators are performing basic...

Lower urinary tract symptoms (LUTS) including overactive bladder, incontinence and flaccid bladder may be the most common complication for patients with diabetes, affecting up to 80–90% of patients by some estimates. We wanted to know which of the mouse strains with high blood glucose would develop...

Prior studies identify brain/spinal cord regions involved in controlling bladder function, but often do not resolve neuronal subpopulations or their specific connections. We seek to develop in mice a complete circuit map of the control of bladder filling and voiding. Prior work and our own...

Functional MRI Processing for Mouse Micturition Studies Functional MRI (fMRI) studies in rodents is somewhat uncommon as it requires some cognitive or physiological stimulus that causes measurable changes in brain activity. This project however, lends itself well to fMRI studies as voiding induced...