John C Mathai, PhD
John C Mathai, PhD
Assistant Professor of Medicine
Harvard Medical School
jmathai@bidmc.harvard.edu
617-667-5845
Dr. Mathai's research interests span across areas as disparate as the biophysics of membrane transport of solutes and gases to the neural control of bladder function. We are currently working on figuring out mechanisms of neural: bladder signaling and its control by the brain. Using genetically engineered mice and monitoring calcium signals in neurons of interest by in vivo fiber photometry we plan to map the coordination of brain centers involved in bladder function. The ultimate goal is to identify the neurogenic causes of incontinence, a leading cause of reduced quality of life for millions of people.
Dr. Mathai’s research focuses on:
1. Neural control of urinary continence:
Using mice as model systems, he is interested in studying how the brain controls the micturition reflex to maintain continence. His specific area of interest is in how continence is maintained during normal sleep. His group uses state-of-the-art methods including optogenetics, fiberphotometry, X-ray videocystometry, and micturition videothermography to probe the brain circuits involved in maintaining continence.
2. Membrane transport:
He has spent many years studying the mechanisms by which small molecules such as water, urea, CO2 and H2S permeate through lipid membranes and protein channels such as aquaporins and urea transporters.